
DOI . ORG {
}
Title[redir]:
MicroRNA regulation in cancer-associated fibroblasts | Cancer Immunology, Immunotherapy
Description:
The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
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article, google, scholar, pubmed, cancer, cas, fibroblasts, tumor, cell, cells, microrna, cancerassociated, breast, microenvironment, res, research, stromal, stroma, content, access, nat, polyak, human, biol, privacy, cookies, aprelikova, green, metastatic, normal, expression, micrornas, myofibroblasts, wang, nature, information, publish, search, review, biology, role, rev, genet, growth, richardson, epithelial, prostate, hanahan, dev, tumorigenesis,
Topics {βοΈ}
col-i-enriched fibrotic environment month download article/chapter bone-marrow-derived myofibroblasts contribute nf-kappab-dependent manner orchestrate tumor-promoting inflammation elevated sdf-1/cxcl12 secretion nf-kappab-dependent induction tlr-triggered dendritic cells article cancer immunology full article pdf cancer-induced stromal reaction privacy choices/manage cookies bone marrow contribution focussed research reviews human cancer metastasis affects tumor biology related subjects metastasis-related micrornas independent genetic alterations hypoxia-mediated selection intramural research program microenvironment cross-talk breast cancers article aprelikova primary breast cancer tumor cell proliferation tumour-stroma interaction epithelium reveals multiplicity frequent somatic mutations innate immune responses breast cancer stroma dormant cells induced gene expression occur normal prostate fibroblasts european economic area present recent advances suppress neoplastic development normal colonic mucosa cantemir-stone cz tlsty td da silva sd mutual paracrine effects rate-limiting determinant deliver small rna mar-binding protein organizations imply endorsement pleiotropically acting microrna microrna 148a production important stromal components anti-cancer therapy
Questions {β}
- Micke P, Ostman A (2004) Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
- Radisky DC, Kenny PA, Bissell MJ (2007) Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
- Rubin H (2008) Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?
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headline:MicroRNA regulation in cancer-associated fibroblasts
description:The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
datePublished:2011-11-16T00:00:00Z
dateModified:2011-11-16T00:00:00Z
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pageEnd:237
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Cancer-associated fibroblasts
MicroRNA
Microenvironment
Tumor
CITIM 2011
Oncology
Immunology
Cancer Research
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headline:MicroRNA regulation in cancer-associated fibroblasts
description:The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
datePublished:2011-11-16T00:00:00Z
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Cancer-associated fibroblasts
MicroRNA
Microenvironment
Tumor
CITIM 2011
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