We are analyzing https://link.springer.com/article/10.1007/s00262-011-1139-7.

Title:
MicroRNA regulation in cancer-associated fibroblasts | Cancer Immunology, Immunotherapy
Description:
The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, google, scholar, pubmed, cancer, cas, fibroblasts, tumor, cell, cells, microrna, cancerassociated, breast, microenvironment, res, research, stromal, stroma, content, access, nat, polyak, human, biol, privacy, cookies, aprelikova, green, metastatic, normal, expression, micrornas, myofibroblasts, wang, nature, information, publish, search, review, biology, role, rev, genet, growth, richardson, epithelial, prostate, hanahan, dev, tumorigenesis,

Topics {✒️}

col-i-enriched fibrotic environment month download article/chapter bone-marrow-derived myofibroblasts contribute nf-kappab-dependent manner orchestrate tumor-promoting inflammation elevated sdf-1/cxcl12 secretion nf-kappab-dependent induction tlr-triggered dendritic cells article cancer immunology full article pdf cancer-induced stromal reaction privacy choices/manage cookies bone marrow contribution focussed research reviews human cancer metastasis affects tumor biology related subjects metastasis-related micrornas independent genetic alterations hypoxia-mediated selection intramural research program microenvironment cross-talk breast cancers article aprelikova primary breast cancer tumor cell proliferation tumour-stroma interaction epithelium reveals multiplicity frequent somatic mutations innate immune responses breast cancer stroma dormant cells induced gene expression occur normal prostate fibroblasts european economic area present recent advances suppress neoplastic development normal colonic mucosa cantemir-stone cz tlsty td da silva sd mutual paracrine effects rate-limiting determinant deliver small rna mar-binding protein organizations imply endorsement pleiotropically acting microrna microrna 148a production important stromal components anti-cancer therapy

Questions {❓}

Micke P, Ostman A (2004) Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Radisky DC, Kenny PA, Bissell MJ (2007) Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
Rubin H (2008) Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:MicroRNA regulation in cancer-associated fibroblasts
         description:The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
         datePublished:2011-11-16T00:00:00Z
         dateModified:2011-11-16T00:00:00Z
         pageStart:231
         pageEnd:237
         sameAs:https://doi.org/10.1007/s00262-011-1139-7
         keywords:
            Cancer-associated fibroblasts
            MicroRNA
            Microenvironment
            Tumor
            CITIM 2011
            Oncology
            Immunology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig3_HTML.gif
         isPartOf:
            name:Cancer Immunology, Immunotherapy
            issn:
               1432-0851
               0340-7004
            volumeNumber:61
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Olga Aprelikova
               affiliation:
                     name:National Cancer Institute
                     address:
                        name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jeffrey E. Green
               affiliation:
                     name:National Cancer Institute
                     address:
                        name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:MicroRNA regulation in cancer-associated fibroblasts
      description:The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive and metastatic disease. Compared to normal tissue, dramatic differences in gene expression occur in multiple cell types that constitute the tumor microenvironment including cancer-associated fibroblasts (CAFs) that are important stromal components of growing tumors. In this review, we present recent advances in understanding how microRNAs are deregulated in cancer-associated fibroblasts (CAFs) and how this affects tumor biology. The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis.
      datePublished:2011-11-16T00:00:00Z
      dateModified:2011-11-16T00:00:00Z
      pageStart:231
      pageEnd:237
      sameAs:https://doi.org/10.1007/s00262-011-1139-7
      keywords:
         Cancer-associated fibroblasts
         MicroRNA
         Microenvironment
         Tumor
         CITIM 2011
         Oncology
         Immunology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-011-1139-7/MediaObjects/262_2011_1139_Fig3_HTML.gif
      isPartOf:
         name:Cancer Immunology, Immunotherapy
         issn:
            1432-0851
            0340-7004
         volumeNumber:61
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Olga Aprelikova
            affiliation:
                  name:National Cancer Institute
                  address:
                     name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jeffrey E. Green
            affiliation:
                  name:National Cancer Institute
                  address:
                     name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer Immunology, Immunotherapy
      issn:
         1432-0851
         0340-7004
      volumeNumber:61
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Cancer Institute
      address:
         name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
         type:PostalAddress
      name:National Cancer Institute
      address:
         name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Olga Aprelikova
      affiliation:
            name:National Cancer Institute
            address:
               name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jeffrey E. Green
      affiliation:
            name:National Cancer Institute
            address:
               name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
      name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(200)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.58s.

LINK . SPRINGER . COM {}