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Title:
Computational prediction of Mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology | Tumor Biology
Description:
Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology. Many vital processes are controlled in the nucleus, where the proteins targeting M. hominis may have various potential implications. A total of 29/563 M. hominis proteins were predicted to target the nucleus of host cells. These include numerous proteins with the capability to alter normal growth activities. In conclusion, our results emphasize that various proteins of M. hominis targeted the nucleus of host cells and were involved in prostate cancer etiology through different mechanisms and strategies.
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pubmed, article, google, scholar, cancer, cas, central, prostate, hominis, mycoplasma, proteins, cell, cells, human, biol, protein, host, infection, nuclear, research, nucleus, khan, localization, gene, targeting, etiology, infections, plos, res, privacy, cookies, content, information, search, tumor, prediction, bacterial, growth, access, inflammation, bmc, mycoplasmas, rev, transformation, dna, chem, publish, biology, shahanavaj, transfer,
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month download article/chapter methyl-cpg binding proteins molecular cell biology swiss-prot protein knowledgebase tumor suppressor role lateral gene transfer full article pdf horizontal gene transfer human prostate cancer prostate cancer etiology activity-based profiling c-myc oncogenes molecular biology privacy choices/manage cookies hominis proteins targeting article khan de marzo human prostate cells include numerous proteins prostate cancer due suspected prostate cancer] human breast cancer prostate cancer cells cancer gene therapy induce malignant transformation multistage malignant transformation universal protein knowledgebase wu ch gene expression modulation curr gene ther nuclear localization signal nat rev cancer cancer metastasis rev related subjects host cell responses mol cell biol universal protein resource breast cancer res rodent fibroblast transformation logunov dy aberrant dna replication nat rev urol article log european economic area curr urol rep amino acid compositions activates nf-kappab high-level expression rna polymerase ii prokaryotic rna polymerases
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- Do mycoplasmas cause human cancer?
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headline:Computational prediction of Mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology
description:Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology. Many vital processes are controlled in the nucleus, where the proteins targeting M. hominis may have various potential implications. A total of 29/563 M. hominis proteins were predicted to target the nucleus of host cells. These include numerous proteins with the capability to alter normal growth activities. In conclusion, our results emphasize that various proteins of M. hominis targeted the nucleus of host cells and were involved in prostate cancer etiology through different mechanisms and strategies.
datePublished:2016-02-13T00:00:00Z
dateModified:2016-02-13T00:00:00Z
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Mycoplasma hominis
Protein targeting
In silico
Host nucleus
Prostate cancer
Etiology
Cancer Research
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headline:Computational prediction of Mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology
description:Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology. Many vital processes are controlled in the nucleus, where the proteins targeting M. hominis may have various potential implications. A total of 29/563 M. hominis proteins were predicted to target the nucleus of host cells. These include numerous proteins with the capability to alter normal growth activities. In conclusion, our results emphasize that various proteins of M. hominis targeted the nucleus of host cells and were involved in prostate cancer etiology through different mechanisms and strategies.
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Mycoplasma hominis
Protein targeting
In silico
Host nucleus
Prostate cancer
Etiology
Cancer Research
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