
DOI . ORG {
}
Title[redir]:
Empowering self-renewal and differentiation: the role of mitochondria in stem cells | Journal of Molecular Medicine
Description:
Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote โstemnessโ in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
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Keywords {๐}
stem, article, google, scholar, pubmed, cells, cas, cell, human, differentiation, mitochondrial, embryonic, cancer, mitochondria, pluripotent, selfrenewal, rehman, pluripotency, nat, rev, induced, metabolism, aging, privacy, cookies, function, content, journal, research, jalees, mol, biol, circulation, lee, publish, search, medicine, role, oxidative, access, kim, doijcell, cardiovascular, heart, res, oxygen, data, information, log, molecular,
Topics {โ๏ธ}
month download article/chapter pluripotent stem cells embryonic stem cells multi-lineage differentiation potential full article pdf induces oxidative stress mediate stem cell deconstructing stem cell stem cell competence developmental biology privacy choices/manage cookies stem cell function murry ce pi jalees rehman adult stem cells mesenchymal stromal cells human-animal chimera cardiovascular cell therapy mitochondrial oxidative metabolism heart research foundation dang cv article rehman hypoxia-inducible factors avoiding lineage commitment functional cardiomyocytes derived specific mitochondrial pathways mitochondrial dna replication mitochondrial dna proliferation mitochondrial respiratory chain european economic area recent studies demonstrate enable metabolic programming clinically relevant populations ischemic heart disease acute myocardial infarction normalization promotes apoptosis vander jagt dl inhibits tumor progression long-term propagation nih-k08-hl080082 article journal stem cells stem cells 26 stem cells 27 stem cells 28 ward-van oostwaard van den brink van der heyden cell-cycle regulation conditions privacy policy
Questions {โ}
- Gogvadze V, Orrenius S, Zhivotovsky B (2008) Mitochondria in cancer cells: what is so special about them?
- Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?
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headline:Empowering self-renewal and differentiation: the role of mitochondria in stem cells
description:Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote โstemnessโ in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
datePublished:2010-09-01T00:00:00Z
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headline:Empowering self-renewal and differentiation: the role of mitochondria in stem cells
description:Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote โstemnessโ in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
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