We are analyzing https://link.springer.com/article/10.1007/s00109-010-0678-2.

Title:
Empowering self-renewal and differentiation: the role of mitochondria in stem cells | Journal of Molecular Medicine
Description:
Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote “stemness” in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

stem, article, google, scholar, pubmed, cells, cas, cell, human, differentiation, mitochondrial, embryonic, cancer, mitochondria, pluripotent, selfrenewal, rehman, pluripotency, nat, rev, induced, metabolism, aging, privacy, cookies, function, content, journal, research, jalees, mol, biol, circulation, lee, publish, search, medicine, role, oxidative, access, kim, doijcell, cardiovascular, heart, res, oxygen, data, information, log, molecular,

Topics {✒️}

month download article/chapter pluripotent stem cells embryonic stem cells multi-lineage differentiation potential full article pdf induces oxidative stress mediate stem cell deconstructing stem cell stem cell competence developmental biology privacy choices/manage cookies stem cell function murry ce pi jalees rehman adult stem cells mesenchymal stromal cells human-animal chimera cardiovascular cell therapy mitochondrial oxidative metabolism heart research foundation dang cv article rehman hypoxia-inducible factors avoiding lineage commitment functional cardiomyocytes derived specific mitochondrial pathways mitochondrial dna replication mitochondrial dna proliferation mitochondrial respiratory chain european economic area recent studies demonstrate enable metabolic programming clinically relevant populations ischemic heart disease acute myocardial infarction normalization promotes apoptosis vander jagt dl inhibits tumor progression long-term propagation nih-k08-hl080082 article journal stem cells stem cells 26 stem cells 27 stem cells 28 ward-van oostwaard van den brink van der heyden cell-cycle regulation conditions privacy policy

Questions {❓}

Gogvadze V, Orrenius S, Zhivotovsky B (2008) Mitochondria in cancer cells: what is so special about them?
Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Empowering self-renewal and differentiation: the role of mitochondria in stem cells
         description:Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote “stemness” in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
         datePublished:2010-09-01T00:00:00Z
         dateModified:2010-09-01T00:00:00Z
         pageStart:981
         pageEnd:986
         sameAs:https://doi.org/10.1007/s00109-010-0678-2
         keywords:
            Stem cells
            Cardiovascular
            Metabolism
            Mitochondria
            Differentiation
            Self-renewal
            Proliferation
            Molecular Medicine
            Human Genetics
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0678-2/MediaObjects/109_2010_678_Fig1_HTML.gif
         isPartOf:
            name:Journal of Molecular Medicine
            issn:
               1432-1440
               0946-2716
            volumeNumber:88
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jalees Rehman
               affiliation:
                     name:University of Chicago
                     address:
                        name:Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Empowering self-renewal and differentiation: the role of mitochondria in stem cells
      description:Stem cells are characterized by their multi-lineage differentiation potential (pluripotency) and their ability for self-renewal, which permits them to proliferate while avoiding lineage commitment and senescence. Recent studies demonstrate that undifferentiated, pluripotent stem cells display lower levels of mitochondrial mass and oxidative phosphorylation, and instead preferentially use non-oxidative glycolysis as a major source of energy. Hypoxia is a potent suppressor of mitochondrial oxidation and appears to promote “stemness” in adult and embryonic stem cells. This has lead to an emerging paradigm, that mitochondrial oxidative metabolism is not just an indicator of the undifferentiated state of stem cells, but may also regulate the pluripotency and self-renewal of stem cells. The identification of specific mitochondrial pathways that regulate stem cell fate may therefore enable metabolic programming and reprogramming of stem cells.
      datePublished:2010-09-01T00:00:00Z
      dateModified:2010-09-01T00:00:00Z
      pageStart:981
      pageEnd:986
      sameAs:https://doi.org/10.1007/s00109-010-0678-2
      keywords:
         Stem cells
         Cardiovascular
         Metabolism
         Mitochondria
         Differentiation
         Self-renewal
         Proliferation
         Molecular Medicine
         Human Genetics
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0678-2/MediaObjects/109_2010_678_Fig1_HTML.gif
      isPartOf:
         name:Journal of Molecular Medicine
         issn:
            1432-1440
            0946-2716
         volumeNumber:88
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jalees Rehman
            affiliation:
                  name:University of Chicago
                  address:
                     name:Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Molecular Medicine
      issn:
         1432-1440
         0946-2716
      volumeNumber:88
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Chicago
      address:
         name:Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jalees Rehman
      affiliation:
            name:University of Chicago
            address:
               name:Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Section of Cardiology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(197)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.38s.

LINK . SPRINGER . COM {}