Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00044-020-02535-2, but it redirected us to https://link.springer.com/article/10.1007/s00044-020-02535-2. The analysis below is for the second page.

Title[redir]:
Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent | Medicinal Chemistry Research
Description:
A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβˆ’ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45 ¡g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08–0.14 mg/ml; bacteria, 0.3–1.4 mg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Careers

Content Management System {πŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of doi.org audience?

πŸ™οΈ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 98,426,998 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {πŸ’Έ}

We're unsure how the site profits.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {πŸ”}

article, google, scholar, synthesis, anticancer, antimicrobial, university, research, chem, king, department, saudi, arabia, chemistry, cas, college, content, trithiocarbonate, access, khalid, pharmacy, box, abha, privacy, cookies, mabkhot, sultan, activity, patent, information, publish, search, medicinal, biological, yahia, khaled, compound, agents, filled, issued, med, springer, data, log, journal, screening, potential, published, april, nasser,

Topics {βœ’οΈ}

month download article/chapter abdullatif bin muhsinah central Ξ²-enaminone motif antifungal activity access enaminone-based heterocyclic compounds yahia nasser mabkhot related subjects full article pdf el-zahrani zaa privacy choices/manage cookies medicinal chemistry anticancer drug development abdulrhman alsayari tyrosine kinase inhibitors trithiocarbonate class engrafted nickel trithiocarbonate compounds article mabkhot enaminone-grafted trithiocarbonate european economic area minimal inhibitory concentrations carbonic anhydrase inhibitors aqueous solution comprising poisonous plants center king khalid university king saud university conditions privacy policy treat major diseases abdel-aziz ha antibiot resistance crisis molecular modeling studies accepting optional cookies bond lengths determined al-showiman ss global cancer statistics ethics declarations conflict pharmaceutical chemistry antimicrobial agents advanced materials science article log scientific research author information authors journal finder publish check access instant access cell growth biological activity article cite elmessery sm young dc antimicrobial agent

Schema {πŸ—ΊοΈ}

WebPage:
      mainEntity:
         headline:Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent
         description:A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβˆ’ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45 ¡g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08–0.14 mg/ml; bacteria, 0.3–1.4 mg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
         datePublished:2020-04-21T00:00:00Z
         dateModified:2020-04-21T00:00:00Z
         pageStart:954
         pageEnd:961
         sameAs:https://doi.org/10.1007/s00044-020-02535-2
         keywords:
            Trithiocarbonate
            Anticancer
            Antibacterial
            Antifungal
            Pharmacology/Toxicology
            Biochemistry
            general
            Medicinal Chemistry
            Bioorganic Chemistry
            Inorganic Chemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Sch1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig7_HTML.png
         isPartOf:
            name:Medicinal Chemistry Research
            issn:
               1554-8120
               1054-2523
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yahia Nasser Mabkhot
               affiliation:
                     name:King Khalid University
                     address:
                        name:Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jamal M. A. Khaled
               affiliation:
                     name:King Saud University
                     address:
                        name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mujeeb A. S. Sultan
               affiliation:
                     name:Aljanad University
                     address:
                        name:Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen
                        type:PostalAddress
                     type:Organization
                     name:College of Sciences
                     address:
                        name:Department of Chemistry, College of Sciences, Riyadh, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Naiyf S. H. A. Alharbi
               affiliation:
                     name:King Saud University
                     address:
                        name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hazem A. Ghabbour
               affiliation:
                     name:University of Mansoura
                     address:
                        name:Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fahd A. Nasr
               affiliation:
                     name:King Saud University
                     address:
                        name:Medicinal Aromatic and Poisonous Plants Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abdulrhman Alsayari
               affiliation:
                     name:King Khalid University
                     address:
                        name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abdullatif Bin Muhsinah
               affiliation:
                     name:King Khalid University
                     address:
                        name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hamed Algarni
               affiliation:
                     name:King Khalid University
                     address:
                        name:Department of Physics, College of Science, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
                     name:King Khalid University
                     address:
                        name:Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yahya I. Asiri
               affiliation:
                     name:King Khalid University
                     address:
                        name:Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent
      description:A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβˆ’ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45 ¡g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08–0.14 mg/ml; bacteria, 0.3–1.4 mg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
      datePublished:2020-04-21T00:00:00Z
      dateModified:2020-04-21T00:00:00Z
      pageStart:954
      pageEnd:961
      sameAs:https://doi.org/10.1007/s00044-020-02535-2
      keywords:
         Trithiocarbonate
         Anticancer
         Antibacterial
         Antifungal
         Pharmacology/Toxicology
         Biochemistry
         general
         Medicinal Chemistry
         Bioorganic Chemistry
         Inorganic Chemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Sch1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00044-020-02535-2/MediaObjects/44_2020_2535_Fig7_HTML.png
      isPartOf:
         name:Medicinal Chemistry Research
         issn:
            1554-8120
            1054-2523
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yahia Nasser Mabkhot
            affiliation:
                  name:King Khalid University
                  address:
                     name:Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jamal M. A. Khaled
            affiliation:
                  name:King Saud University
                  address:
                     name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mujeeb A. S. Sultan
            affiliation:
                  name:Aljanad University
                  address:
                     name:Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen
                     type:PostalAddress
                  type:Organization
                  name:College of Sciences
                  address:
                     name:Department of Chemistry, College of Sciences, Riyadh, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Naiyf S. H. A. Alharbi
            affiliation:
                  name:King Saud University
                  address:
                     name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hazem A. Ghabbour
            affiliation:
                  name:University of Mansoura
                  address:
                     name:Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fahd A. Nasr
            affiliation:
                  name:King Saud University
                  address:
                     name:Medicinal Aromatic and Poisonous Plants Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abdulrhman Alsayari
            affiliation:
                  name:King Khalid University
                  address:
                     name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abdullatif Bin Muhsinah
            affiliation:
                  name:King Khalid University
                  address:
                     name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hamed Algarni
            affiliation:
                  name:King Khalid University
                  address:
                     name:Department of Physics, College of Science, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
                  name:King Khalid University
                  address:
                     name:Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yahya I. Asiri
            affiliation:
                  name:King Khalid University
                  address:
                     name:Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medicinal Chemistry Research
      issn:
         1554-8120
         1054-2523
      volumeNumber:29
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:King Khalid University
      address:
         name:Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Saud University
      address:
         name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
         type:PostalAddress
      name:Aljanad University
      address:
         name:Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen
         type:PostalAddress
      name:College of Sciences
      address:
         name:Department of Chemistry, College of Sciences, Riyadh, Saudi Arabia
         type:PostalAddress
      name:King Saud University
      address:
         name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
         type:PostalAddress
      name:University of Mansoura
      address:
         name:Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
         type:PostalAddress
      name:King Saud University
      address:
         name:Medicinal Aromatic and Poisonous Plants Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Department of Physics, College of Science, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yahia Nasser Mabkhot
      affiliation:
            name:King Khalid University
            address:
               name:Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jamal M. A. Khaled
      affiliation:
            name:King Saud University
            address:
               name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Mujeeb A. S. Sultan
      affiliation:
            name:Aljanad University
            address:
               name:Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen
               type:PostalAddress
            type:Organization
            name:College of Sciences
            address:
               name:Department of Chemistry, College of Sciences, Riyadh, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Naiyf S. H. A. Alharbi
      affiliation:
            name:King Saud University
            address:
               name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Hazem A. Ghabbour
      affiliation:
            name:University of Mansoura
            address:
               name:Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
               type:PostalAddress
            type:Organization
      name:Fahd A. Nasr
      affiliation:
            name:King Saud University
            address:
               name:Medicinal Aromatic and Poisonous Plants Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Abdulrhman Alsayari
      affiliation:
            name:King Khalid University
            address:
               name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Abdullatif Bin Muhsinah
      affiliation:
            name:King Khalid University
            address:
               name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Hamed Algarni
      affiliation:
            name:King Khalid University
            address:
               name:Department of Physics, College of Science, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
            name:King Khalid University
            address:
               name:Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Yahya I. Asiri
      affiliation:
            name:King Khalid University
            address:
               name:Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
      name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
      name:Department of Pharmacy, Faculty of Medical Sciences, Aljanad University, Taiz, Republic of Yemen
      name:Department of Chemistry, College of Sciences, Riyadh, Saudi Arabia
      name:Department of Botany and Microbiology, College of Science, King Saud University, Abha, Saudi Arabia
      name:Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
      name:Medicinal Aromatic and Poisonous Plants Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
      name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
      name:Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
      name:Department of Physics, College of Science, King Khalid University, Abha, Saudi Arabia
      name:Research Centre for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia
      name:Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {πŸ”—}(131)

Analytics and Tracking {πŸ“Š}

  • Google Tag Manager

Libraries {πŸ“š}

  • Clipboard.js
  • Prism.js

Emails and Hosting {βœ‰οΈ}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {πŸ“¦}

  • Crossref

4.68s.