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Title:
Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent | Medicinal Chemistry Research
Description:
A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45βΒ΅g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08β0.14βmg/ml; bacteria, 0.3β1.4βmg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
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month download article/chapter abdullatif bin muhsinah central Ξ²-enaminone motif antifungal activity access enaminone-based heterocyclic compounds yahia nasser mabkhot related subjects full article pdf el-zahrani zaa privacy choices/manage cookies medicinal chemistry anticancer drug development abdulrhman alsayari tyrosine kinase inhibitors trithiocarbonate class engrafted nickel trithiocarbonate compounds article mabkhot enaminone-grafted trithiocarbonate european economic area minimal inhibitory concentrations carbonic anhydrase inhibitors aqueous solution comprising poisonous plants center king khalid university king saud university conditions privacy policy treat major diseases abdel-aziz ha antibiot resistance crisis molecular modeling studies accepting optional cookies bond lengths determined al-showiman ss global cancer statistics ethics declarations conflict pharmaceutical chemistry antimicrobial agents advanced materials science article log scientific research author information authors journal finder publish check access instant access cell growth biological activity article cite elmessery sm young dc antimicrobial agent
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headline:Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent
description:A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45βΒ΅g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08β0.14βmg/ml; bacteria, 0.3β1.4βmg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
datePublished:2020-04-21T00:00:00Z
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Anticancer
Antibacterial
Antifungal
Pharmacology/Toxicology
Biochemistry
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Bioorganic Chemistry
Inorganic Chemistry
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description:A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate class engrafted by an enaminone group. The anticancer and antimicrobial activities were evaluated by utilizing three different types of human cancer (MDA-MB-231, LoVo, and HepG2) and a wide field of microbes (G+ and Gβ bacteria, yeast, and molds). The tested compound 3 exhibited moderate growth suppression activity versus all examined human tumor cells, with values of IC50 ranging from 35 to 45βΒ΅g/ml. Moreover, the antimicrobial effects of compound 3 were more profound against fungal pathogens than against bacterial pathogens (minimal inhibitory concentrations; fungi, 0.08β0.14βmg/ml; bacteria, 0.3β1.4βmg/ml). These findings lay the foundation for designing improved bioactive agents that could be utilized as anticancer and/or antimicrobial agents.
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