DOI . ORG {}

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We began analyzing https://link.springer.com/chapter/10.1007/978-3-642-61109-4_5, but it redirected us to https://link.springer.com/chapter/10.1007/978-3-642-61109-4_5. The analysis below is for the second page.

Title[redir]:
Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System | SpringerLink
Description:
The brain is a unique target for tumor invasion and metastasis formation (Steck and Nicolson 1993; Nicolson 1993a; Menter et al. 1995a; Nicolson et al. 1994b. The central nervous system (CNS) is confined by the skull, and the brain is highly sensitive to the...

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🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 80,904,851 visitors per month in the current month.

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Keywords {🔍}

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a-melanocyte-stimulating hormone release low-affinity ngf receptor low-affinity neurotrophin receptor brain-derived neurotrophic factor ceramide-mediated signal transduction fibroblast-derived growth inhibitor nucleotide affinity-exchange chromatography lung-derived growth factor ceramide-activated protein phosphatase mitogen-activated protein kinases tumor necrosis factor-alpha nerve growth factor month download article/chapter ngf-induced neuronal differentiation fibroblast growth factor formidable blood-brain barrier ciliary neurotrophic factor paracrine/autocrine growth mechanisms melanocyte stimulating hormone biological activity ngf autocrine/paracrine growth factors high affinity receptors growth factor receptors human ngf receptor growth factor cdnas trk binding sites lung-metastasizing tumor cells human melanocyte growth peripheral inflammation induced phospholipase c-gamma 1 lung-derived growth neurotrophin induced camp signal transduction pathway limb proprioceptive afferents smooth muscle pericytes privacy choices/manage cookies tnf receptor superfamily autocrine growth mechanisms central nervous system growth regulatory factors device instant download potentiate functional responses paracrine growth factors protein kinases erk1 peripheral nervous system major complication resulting intracellular signaling pathways hempstead bl neurotrophin-3 enhances sprouting specific secondary sites

Schema {🗺️}

ScholarlyArticle:
      headline:Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System
      pageEnd:115
      pageStart:89
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-61109-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Attempts to Understand Metastasis Formation II
         isbn:
            978-3-642-61109-4
            978-3-642-64698-0
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         name:Springer Berlin Heidelberg
         logo:
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      author:
            name:G. L. Nicolson
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D. G. Menter
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. L. Herrmann
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Z. Yun
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. Cavanaugh
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D. Marchetti
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Melanoma Cell, Brain Metastasis, Nerve Growth Factor, Paracrine Factor, Neurotrophin Receptor
      description:The brain is a unique target for tumor invasion and metastasis formation (Steck and Nicolson 1993; Nicolson 1993a; Menter et al. 1995a; Nicolson et al. 1994b. The central nervous system (CNS) is confined by the skull, and the brain is highly sensitive to the slightest change in the local microenvironment. The brain is also surrounded by a formidable blood-brain barrier (BBB), which does not allow penetration of most cell types. Because the brain lacks lymphatic drainage, cerebral edema is a major complication resulting from tumors in the CNS. When tumors form in the brain, either from endogenous brain cells or from metastases invading the BBB, they are very difficult to successfully treat. Therapy of brain tumors and metastases are often only palliative and are often accompanied by additional complications. A relatively small tumor in the brain cavity can cause severe symptoms, including impaired cognition, headaches, seizures, and eventually paralysis.
      datePublished:1996
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Book:
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      isbn:
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      name:Springer Berlin Heidelberg
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      name:University of Texas, MD Anderson Cancer Center
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         name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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         name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:D. G. Menter
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:J. L. Herrmann
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
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      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:P. Cavanaugh
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
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               type:PostalAddress
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      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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