We are analyzing https://link.springer.com/chapter/10.1007/978-3-642-61109-4_5.

Title:
Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System | SpringerLink
Description:
The brain is a unique target for tumor invasion and metastasis formation (Steck and Nicolson 1993; Nicolson 1993a; Menter et al. 1995a; Nicolson et al. 1994b. The central nervous system (CNS) is confined by the skull, and the brain is highly sensitive to the...
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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System
      pageEnd:115
      pageStart:89
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-61109-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Attempts to Understand Metastasis Formation II
         isbn:
            978-3-642-61109-4
            978-3-642-64698-0
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:G. L. Nicolson
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D. G. Menter
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. L. Herrmann
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Z. Yun
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. Cavanaugh
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D. Marchetti
            affiliation:
                  name:University of Texas, MD Anderson Cancer Center
                  address:
                     name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Melanoma Cell, Brain Metastasis, Nerve Growth Factor, Paracrine Factor, Neurotrophin Receptor
      description:The brain is a unique target for tumor invasion and metastasis formation (Steck and Nicolson 1993; Nicolson 1993a; Menter et al. 1995a; Nicolson et al. 1994b. The central nervous system (CNS) is confined by the skull, and the brain is highly sensitive to the slightest change in the local microenvironment. The brain is also surrounded by a formidable blood-brain barrier (BBB), which does not allow penetration of most cell types. Because the brain lacks lymphatic drainage, cerebral edema is a major complication resulting from tumors in the CNS. When tumors form in the brain, either from endogenous brain cells or from metastases invading the BBB, they are very difficult to successfully treat. Therapy of brain tumors and metastases are often only palliative and are often accompanied by additional complications. A relatively small tumor in the brain cavity can cause severe symptoms, including impaired cognition, headaches, seizures, and eventually paralysis.
      datePublished:1996
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Book:
      name:Attempts to Understand Metastasis Formation II
      isbn:
         978-3-642-61109-4
         978-3-642-64698-0
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      name:Springer Berlin Heidelberg
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      name:University of Texas, MD Anderson Cancer Center
      address:
         name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:University of Texas, MD Anderson Cancer Center
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         name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:University of Texas, MD Anderson Cancer Center
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         name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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      name:G. L. Nicolson
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:D. G. Menter
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:J. L. Herrmann
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Z. Yun
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:P. Cavanaugh
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:D. Marchetti
      affiliation:
            name:University of Texas, MD Anderson Cancer Center
            address:
               name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
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      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
      name:Department of Tumor Biology, University of Texas, MD Anderson Cancer Center, Houston, USA
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