
DOI . ORG {
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Title[redir]:
Functions of Tie1 and Tie2 Receptor Tyrosine Kinases in Vascular Development | SpringerLink
Description:
Vascularization of the mouse embryo is accomplished via the collaboration of two major cellular processes. Differentiation of vascular endothelial cells de novo from their precursors, called the angioblasts, has been termed vasculogenesis (Risau 1997). Somewhat...
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Keywords {π}
google, scholar, pubmed, cas, article, receptor, tyrosine, tie, kinase, endothelial, vascular, cell, cells, development, expression, alitalo, angiogenesis, growth, chapter, dumont, protein, partanen, nature, vasculogenesis, kinases, blood, oncogene, mouse, expressed, genes, rossant, breitman, risau, pardanaud, embryonic, sato, privacy, cookies, content, information, publish, embryo, mesoderm, download, korhonen, leukemia, human, factor, sci, usa,
Topics {βοΈ}
inositol polyphosphate-5-phosphatase activity month download article/chapter receptor tyrosine kinases receptor tyrosine kinase secretion-trap expression cloning c-etsl proto-oncogene vascular growth factors van der zee tie gene promoter dok-related docking protein transcription factor expressed privacy choices/manage cookies megakaryocyte-specific genes endothelial cell lineage vascular endothelial cells constitutively tyrosine-phosphorylated device instant download tie2 receptor expression angiogenic capillary growth growth factor distinct endothelial lineages promoter implicates gata protein module implicated vascular dysmorphogenesis caused endothelial cell survival endothelial cell precursors insulin receptor substrate-1 vascular system defects hematopoietic stem cells tyrosine kinase leukemia cell lines european economic area rat pulmonary microcirculation postnatal rat lung targeted null mutations continuous labelling studies epithelio-mesenchymal specificity mount sinai hospital distinct rat genes journal finder publish download preview pdf abnormal mesoderm patterning cells step backward growth factors mouse embryos mutant adult transgenic mice conditions privacy policy primitive vascular network directed migration multiple chromosomal translocations
Schema {πΊοΈ}
ScholarlyArticle:
headline:Functions of Tie1 and Tie2 Receptor Tyrosine Kinases in Vascular Development
pageEnd:172
pageStart:159
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-59953-8.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Vascular Growth Factors and Angiogenesis
isbn:
978-3-642-59953-8
978-3-642-64195-4
type:Book
publisher:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:J. Partanen
affiliation:
name:Mount Sinai Hospital
address:
name:Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:D. J. Dumont
affiliation:
name:University of Toronto
address:
name:Amgen and Ontario Cancer Institutes, Department of Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
keywords:Receptor Tyrosine Kinase, Vascular Development, Endothelial Cell Lineage, Tie2 Receptor, Vascular Defect
description:Vascularization of the mouse embryo is accomplished via the collaboration of two major cellular processes. Differentiation of vascular endothelial cells de novo from their precursors, called the angioblasts, has been termed vasculogenesis (Risau 1997). Somewhat confusingly, the term vasculogenesis has also been used in a broader sense, covering all aspects of vascular development (Dumont et al. 1994; Noden 1991; Sherer 1991; Wilting and Christ 1996). Subsequent expansion of the endothelium by remodelling, migration and proliferation is called angiogenesis. Vasculogenesis is known to occur intraembryonically within the splanchnopleural and paraxial mesoderm, as well as extraembryonically in the yolk sac mesoderm, and is responsible for laying down the primitive vascular network (Pardanaud et al. 1996; Wilting and Christ 1996). Vasculogenesis is characterized by angioblast differentiation and by either the immediate aggregation of angioblast cells to give rise to endothelium, or the directed migration of these cells through the embryo to segregate eventually into vascular cords. Interestingly, angioblasts appear to have different characteristics depending on their site of origin (Pardanaud et al. 1996). Vasculogenesis both in the yolk sac and in the splanchnic mesoderm appears closely linked to haemangioblast (Pardanaud et al. 1989; Shalaby et al. 1995, 1997).
datePublished:1999
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name:Amgen and Ontario Cancer Institutes, Department of Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
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name:Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
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