
DOI . ORG {
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Title[redir]:
Physicochemical Characterization of Polymer Nanoparticles: Challenges and Present Limitations | SpringerLink
Description:
The biocompatibility, including aspects such as biodistribution, clearance, and immunotoxicity, of a nanoparticle depends upon its physicochemical properties. Characteristics such as size, charge, and hydrophobicity are well-known parameters influencing the...
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ScholarlyArticle:
headline:Physicochemical Characterization of Polymer Nanoparticles: Challenges and Present Limitations
pageEnd:203
pageStart:187
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-41421-8.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Polymer Nanoparticles for Nanomedicines
isbn:
978-3-319-41421-8
978-3-319-41419-5
type:Book
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Jeffrey D. Clogston
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
type:Organization
type:Person
name:Rachael M. Crist
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
type:Organization
type:Person
name:Scott E. McNeil
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Nanoparticles, Physicochemical characterization, Polymer nanoparticles, Polymers
description:The biocompatibility, including aspects such as biodistribution, clearance, and immunotoxicity, of a nanoparticle depends upon its physicochemical properties. Characteristics such as size, charge, and hydrophobicity are well-known parameters influencing the biological compatibility of in vivo administered nanoparticles. Measurement and evaluation of these and other parameters, however, are not always straightforward. This chapter describes six critical areas for nanoparticle characterization, especially as pertaining to polymer nanoparticles intended as therapeutics: starting polymer characterization, nanoparticle size, nanoparticle surface properties, drug loading and release, nanoparticle stability, and batch-to-batch reproducibility. The challenges and limitations of the most common techniques used in assessment of these parameters are described.
datePublished:2016
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Book:
name:Polymer Nanoparticles for Nanomedicines
isbn:
978-3-319-41421-8
978-3-319-41419-5
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name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
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address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
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name:Jeffrey D. Clogston
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
type:Organization
name:Rachael M. Crist
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
type:Organization
name:Scott E. McNeil
affiliation:
name:Frederick National Laboratory for Cancer Research
address:
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
type:PostalAddress
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email:[email protected]
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name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
name:Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
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