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We began analyzing https://link.springer.com/protocol/10.1007/978-1-62703-721-1_9, but it redirected us to https://link.springer.com/protocol/10.1007/978-1-62703-721-1_9. The analysis below is for the second page.

Title[redir]:
Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells | SpringerLink
Description:
DNA methylation, a DNA modification by adding methyl group to cytosine, has an important role in the regulation of gene expression. DNA methylation is known to be associated with gene transcription by interfering with DNA-binding proteins, such as transcription...

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Keywords {🔍}

cancer, methylation, dna, gene, google, scholar, article, pubmed, cas, expression, breast, cpg, analysis, data, protocol, information, kim, privacy, cookies, content, publish, research, molecular, genomic, regions, island, hypermethylation, function, search, chae, genes, cell, subtypes, access, chapter, nature, download, springer, usd, personal, log, journal, effect, lee, evans, book, role, transcription, state, human,

Topics {✒️}

month download article/chapter /jinlab/bmi730/bmi730-10-lecture10 identifying chip-seq enrichment kr/mcpg-snp-express national research foundation including cpg islands gene function analysis tumor phenotypes human breast cancer privacy choices/manage cookies adding methyl group breast cancer patients breast cancer subtypes mcpg-snp-express author information authors breast cancer phenotypes cancer cells protocol rural development administration gene expression patterns device instant download p16 gene methylation affymetrix genechip data cervical cancer patients specific genomic regions european economic area dna-binding proteins check access dna hypomethylation leads elevated mutation rates north indian population ethics access cpg island aberrant dna methylation cpg shore journal finder publish conditions privacy policy protocol lee chapter log transcription start sites cpg shores accepting optional cookies transcriptionally repressed genes breast cancer integrated genomic analyses main content log protocol usd 49 gene expression ohio-state similar content methylation state

Schema {🗺️}

ScholarlyArticle:
      headline:Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells
      pageEnd:178
      pageStart:161
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-62703-721-1.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Gene Function Analysis
         isbn:
            978-1-62703-721-1
            978-1-62703-720-4
         type:Book
      publisher:
         name:Humana Press
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      author:
            name:Chai-Jin Lee
            affiliation:
                  name:Seoul National University
                  address:
                     name:Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jared Evans
            affiliation:
                  name:Seoul National University
                  address:
                     name:Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kwangsoo Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heejoon Chae
            affiliation:
                  name:Seoul National University
                  address:
                     name:Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sun Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:DNA methylation, Gene expression, Breast cancer, CpG island, CpG shore, Exon, Intron
      description:DNA methylation, a DNA modification by adding methyl group to cytosine, has an important role in the regulation of gene expression. DNA methylation is known to be associated with gene transcription by interfering with DNA-binding proteins, such as transcription factors. DNA methylation is closely related to tumorigenesis, and the methylation state of some genes can be used as a biomarker for tumorigenesis. Aberrant DNA methylation of genomic regions, including CpG islands, CpG shores, and first exons, is related to the altered gene expression pattern characteristics of all human cancers. Subheading 1 surveys recent developments on DNA methylation and gene expressions in cancer. Then we provide analysis of DNA methylation and gene expression in 30 breast cancer cell lines representing different tumor phenotypes. This study conducted an integrated analysis to identify the relationship between DNA methylation in various genomic regions and expression levels of downstream genes, using MethylCapseq data (affinity purification followed by next-generation sequencing of eluted DNA) and Affymetrix gene expression microarray data. The goal of this study was to assess genome-wide methylation profiles associated with different molecular subtypes of human breast cancer (luminal, basal A, and basal B) and to comprehensively investigate the effect of DNA methylation on gene expression in breast cancer phenotypes. This showed that methylation of genomic regions near transcription start sites, CpG island, CpG shore, and first exon was strongly associated with gene repression, and the effects of the regions on gene expression patterns were different for different molecular subtypes of breast cancer. The results further indicated that aberrant methylation of specific genomic regions was significantly associated with different breast cancer subtypes.
      datePublished:2014
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Book:
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      isbn:
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      name:Seoul National University
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               name:Seoul National University, Seoul, Korea
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      name:Jared Evans
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               name:Seoul National University, Seoul, Korea
               type:PostalAddress
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      name:Kwangsoo Kim
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               name:Seoul National University, Seoul, Korea
               type:PostalAddress
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      name:Heejoon Chae
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               type:PostalAddress
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      name:Sun Kim
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               name:Seoul National University, Seoul, Korea
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      name:Seoul National University, Seoul, Korea
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