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We are analyzing https://link.springer.com/article/10.1007/s11033-012-1787-5.

Title:
Promoter hypermethylation of p73 and p53 genes in cervical cancer patients among north Indian population | Molecular Biology Reports
Description:
Hypermethylation of CpG islands leads to transcriptional silencing and it is the predominant mechanism of tumor suppressor gene inactivation in many tumors. Methylation-specific polymerase chain reaction was performed to analyse the methylation status of the promoter region of the tumor suppressor genes. Hypermethylation of the 5′ CpG island of the p21 CIP1 , p27 KIP1 , p57 KIP2 , p53, p73 and RB 1 gene promoter were found in 8.8, 8.8, 11.2, 12, 25.6 and 4.8 % of 125 cervical cancer samples from north Indian population, respectively. Methylation of p73 was significantly (P < 0.001) associated with the cervical cancer cases in comparison to controls. Significant correlation was also observed between the methylation of p73 gene and increase in the risk of cervical cancer among passive smokers. Promoter hypermethylation of p53 gene was also observed to be significant among oral contraceptive users and cervical cancer patients having age at first sexual intercourse <20 years whereas hypermethylation of other genes was not found to be significant in the present study. This is the first report showing significant hypermethylation of p73 and p53 genes among cervical cancer patients in north Indian population. This is also the first report on significant p53 hypermethylation in cervical cancer in any population. Our findings did not show any correlation between promoter methylation of p73 and the other genes under study with clinicopathological parameters, including human papillomavirus infection and stage of the disease. The frequency of aberrant methylation of p73 and p53 gene promoter was unchanged according to the age of patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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  • Education
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What CMS is link.springer.com built with?

Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Link.springer.com Make Money? {💸}

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Keywords {🔍}

google, scholar, pubmed, cancer, cas, article, methylation, gene, cervical, hypermethylation, genes, promoter, res, tumor, human, cell, suppressor, patients, analysis, nikbakht, kaur, cpg, kip, oral, dna, blood, pathol, population, jha, role, central, kinase, chen, expression, lymphomas, oncol, kim, leukemia, carcinoma, privacy, cookies, content, research, molecular, north, indian, capalash, island, significant, access,

Topics {✒️}

month download article/chapter gene p21 waf1/cip1/sdi1 p21 cip1/waf1/sdi1 gene cyclin-dependent kinase inhibitor cyclin-dependent kinase inhibitors el-deiry ws selective maternal-allele loss p21 waf1/cip1 gene p21 waf1/cip1 expression fr/globocan/database p53-mediated g1 arrest full article pdf related subjects dna methylation inhibitors privacy choices/manage cookies tumor suppressor genes north indian population article jha serrated neoplasia pathway human dna segment tumor suppressor role p21 waf1/cip1 primary gastrointestinal lymphomas cervical cancer lines p27 kip1 gene gene hypermethylation profile kang cs cervical intraepithelial neoplasia p21 waf1 genes cpg islands leads cervical cancer cases p21cip1/waf1 proteins acute lymphoblastic leukemia p27 gene plays gastric malt lymphomas mantle cell lymphomas european economic area prototypic hereditary neoplasm corn pg dong sm cip/kip families chronic lymphocytic leukaemia infrequent epigenetic dysregulation cip/kip family confers poor prognosis distinct biological entity van noesel mm translocation-negative subtypes financial assistance provided government medical college

Schema {🗺️}

WebPage:
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         headline:Promoter hypermethylation of p73 and p53 genes in cervical cancer patients among north Indian population
         description:Hypermethylation of CpG islands leads to transcriptional silencing and it is the predominant mechanism of tumor suppressor gene inactivation in many tumors. Methylation-specific polymerase chain reaction was performed to analyse the methylation status of the promoter region of the tumor suppressor genes. Hypermethylation of the 5′ CpG island of the p21 CIP1 , p27 KIP1 , p57 KIP2 , p53, p73 and RB 1 gene promoter were found in 8.8, 8.8, 11.2, 12, 25.6 and 4.8 % of 125 cervical cancer samples from north Indian population, respectively. Methylation of p73 was significantly (P < 0.001) associated with the cervical cancer cases in comparison to controls. Significant correlation was also observed between the methylation of p73 gene and increase in the risk of cervical cancer among passive smokers. Promoter hypermethylation of p53 gene was also observed to be significant among oral contraceptive users and cervical cancer patients having age at first sexual intercourse <20 years whereas hypermethylation of other genes was not found to be significant in the present study. This is the first report showing significant hypermethylation of p73 and p53 genes among cervical cancer patients in north Indian population. This is also the first report on significant p53 hypermethylation in cervical cancer in any population. Our findings did not show any correlation between promoter methylation of p73 and the other genes under study with clinicopathological parameters, including human papillomavirus infection and stage of the disease. The frequency of aberrant methylation of p73 and p53 gene promoter was unchanged according to the age of patients.
         datePublished:2012-06-24T00:00:00Z
         dateModified:2012-06-24T00:00:00Z
         pageStart:9145
         pageEnd:9157
         sameAs:https://doi.org/10.1007/s11033-012-1787-5
         keywords:
            Hypermethylation
            MSP
            CpG island
            AFSI
            HPV
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
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               name:Abhimanyu Kumar Jha
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                     address:
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                        type:PostalAddress
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                        name:Department of Gynaecology, Government Medical College and Hospital, Chandigarh, India
                        type:PostalAddress
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               name:Neena Capalash
               affiliation:
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                     address:
                        name:Department of Biotechnology, Panjab University, Chandigarh, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jagdeep Kaur
               affiliation:
                     name:Panjab University
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                        name:Department of Biotechnology, Panjab University, Chandigarh, India
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      headline:Promoter hypermethylation of p73 and p53 genes in cervical cancer patients among north Indian population
      description:Hypermethylation of CpG islands leads to transcriptional silencing and it is the predominant mechanism of tumor suppressor gene inactivation in many tumors. Methylation-specific polymerase chain reaction was performed to analyse the methylation status of the promoter region of the tumor suppressor genes. Hypermethylation of the 5′ CpG island of the p21 CIP1 , p27 KIP1 , p57 KIP2 , p53, p73 and RB 1 gene promoter were found in 8.8, 8.8, 11.2, 12, 25.6 and 4.8 % of 125 cervical cancer samples from north Indian population, respectively. Methylation of p73 was significantly (P < 0.001) associated with the cervical cancer cases in comparison to controls. Significant correlation was also observed between the methylation of p73 gene and increase in the risk of cervical cancer among passive smokers. Promoter hypermethylation of p53 gene was also observed to be significant among oral contraceptive users and cervical cancer patients having age at first sexual intercourse <20 years whereas hypermethylation of other genes was not found to be significant in the present study. This is the first report showing significant hypermethylation of p73 and p53 genes among cervical cancer patients in north Indian population. This is also the first report on significant p53 hypermethylation in cervical cancer in any population. Our findings did not show any correlation between promoter methylation of p73 and the other genes under study with clinicopathological parameters, including human papillomavirus infection and stage of the disease. The frequency of aberrant methylation of p73 and p53 gene promoter was unchanged according to the age of patients.
      datePublished:2012-06-24T00:00:00Z
      dateModified:2012-06-24T00:00:00Z
      pageStart:9145
      pageEnd:9157
      sameAs:https://doi.org/10.1007/s11033-012-1787-5
      keywords:
         Hypermethylation
         MSP
         CpG island
         AFSI
         HPV
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
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                  address:
                     name:Department of Biotechnology, Panjab University, Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohsen Nikbakht
            affiliation:
                  name:Panjab University
                  address:
                     name:Department of Biotechnology, Panjab University, Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Veena Jain
            affiliation:
                  name:Mohan Dai Oswal Cancer Treatment and Research Foundation
                  address:
                     name:Department of Gynaecology, Mohan Dai Oswal Cancer Treatment and Research Foundation, Ludhiana, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alka Sehgal
            affiliation:
                  name:Government Medical College and Hospital
                  address:
                     name:Department of Gynaecology, Government Medical College and Hospital, Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neena Capalash
            affiliation:
                  name:Panjab University
                  address:
                     name:Department of Biotechnology, Panjab University, Chandigarh, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jagdeep Kaur
            affiliation:
                  name:Panjab University
                  address:
                     name:Department of Biotechnology, Panjab University, Chandigarh, India
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         name:Department of Biotechnology, Panjab University, Chandigarh, India
         type:PostalAddress
      name:Mohan Dai Oswal Cancer Treatment and Research Foundation
      address:
         name:Department of Gynaecology, Mohan Dai Oswal Cancer Treatment and Research Foundation, Ludhiana, India
         type:PostalAddress
      name:Government Medical College and Hospital
      address:
         name:Department of Gynaecology, Government Medical College and Hospital, Chandigarh, India
         type:PostalAddress
      name:Panjab University
      address:
         name:Department of Biotechnology, Panjab University, Chandigarh, India
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      name:Abhimanyu Kumar Jha
      affiliation:
            name:Panjab University
            address:
               name:Department of Biotechnology, Panjab University, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Mohsen Nikbakht
      affiliation:
            name:Panjab University
            address:
               name:Department of Biotechnology, Panjab University, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Veena Jain
      affiliation:
            name:Mohan Dai Oswal Cancer Treatment and Research Foundation
            address:
               name:Department of Gynaecology, Mohan Dai Oswal Cancer Treatment and Research Foundation, Ludhiana, India
               type:PostalAddress
            type:Organization
      name:Alka Sehgal
      affiliation:
            name:Government Medical College and Hospital
            address:
               name:Department of Gynaecology, Government Medical College and Hospital, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Neena Capalash
      affiliation:
            name:Panjab University
            address:
               name:Department of Biotechnology, Panjab University, Chandigarh, India
               type:PostalAddress
            type:Organization
      name:Jagdeep Kaur
      affiliation:
            name:Panjab University
            address:
               name:Department of Biotechnology, Panjab University, Chandigarh, India
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Gynaecology, Government Medical College and Hospital, Chandigarh, India
      name:Department of Biotechnology, Panjab University, Chandigarh, India
      name:Department of Biotechnology, Panjab University, Chandigarh, India
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