
DOI . ORG {
}
Title[redir]:
Nuclear Receptors: A Historical Perspective | SpringerLink
Description:
In this chapter, we summarize the birth of the field of nuclear receptors. These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved...
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Keywords {🔍}
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Topics {✒️}
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Schema {🗺️}
ScholarlyArticle:
headline:Nuclear Receptors: A Historical Perspective
pageEnd:5
pageStart:1
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-9195-2.jpg
genre:
Springer Protocols
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isbn:
978-1-4939-9195-2
978-1-4939-9194-5
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publisher:
name:Springer New York
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author:
name:Gisela I. Mazaira
affiliation:
name:Universidad de Buenos Aires
address:
name:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
type:PostalAddress
type:Organization
type:Person
name:Nadia R. Zgajnar
affiliation:
name:Instituto de Biología y Medicina Experimental-CONICET
address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
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affiliation:
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address:
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address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
type:PostalAddress
type:Organization
type:Person
name:Jeffrey C. Sivils
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
type:Person
name:Olga B. Soto
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
type:Person
name:Marc B. Cox
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
type:Person
name:Mario D. Galigniana
affiliation:
name:Universidad de Buenos Aires
address:
name:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
type:PostalAddress
type:Organization
name:Instituto de Biología y Medicina Experimental-CONICET
address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Nuclear receptor, Steroid receptor, Transcriptional regulation
description:In this chapter, we summarize the birth of the field of nuclear receptors. These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral protein acquired various functions upon binding to preexisting small molecules, ligands. Currently, members of this receptor superfamily are categorized in six groups, including “orphan receptors.” Research in the area has resulted in several clinically used drugs and continues to reveal further previously unknown roles for these receptors paving the road toward more valuable discoveries in the future.
datePublished:2019
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address:
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type:PostalAddress
name:Universidad de Buenos Aires
address:
name:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Person:
name:Gisela I. Mazaira
affiliation:
name:Universidad de Buenos Aires
address:
name:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
type:PostalAddress
type:Organization
name:Nadia R. Zgajnar
affiliation:
name:Instituto de Biología y Medicina Experimental-CONICET
address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
type:PostalAddress
type:Organization
name:Cecilia M. Lotufo
affiliation:
name:Instituto de Biología y Medicina Experimental-CONICET
address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
type:PostalAddress
type:Organization
name:Cristina Daneri-Becerra
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name:Instituto de Biología y Medicina Experimental-CONICET
address:
name:Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina
type:PostalAddress
type:Organization
name:Jeffrey C. Sivils
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
name:Olga B. Soto
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
name:Marc B. Cox
affiliation:
name:University of Texas at El Paso
address:
name:Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, USA
type:PostalAddress
type:Organization
name:Mario D. Galigniana
affiliation:
name:Universidad de Buenos Aires
address:
name:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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name:Instituto de Biología y Medicina Experimental-CONICET
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