We are analyzing https://link.springer.com/article/10.1007/s00018-014-1709-x.

Title:
Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration | Cellular and Molecular Life Sciences
Description:
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly in the Western world. Over the last 30 years, our understanding of the pathogenesis of the disease has grown exponentially thanks to the results of countless epidemiology, genetic, histological, and biochemical studies. This information, in turn, has led to the identification of multiple biologic pathways potentially involved in development and progression of AMD, including but not limited to inflammation, lipid and extracellular matrix dysregulation, and angiogenesis. Nuclear receptors are a superfamily of transcription factors that have been shown to regulate many of the pathogenic pathways linked with AMD and as such they are emerging as promising targets for therapeutic intervention. In this review, we will present the fundamental phenotypic features of AMD and discuss our current understanding of the pathobiological disease mechanisms. We will introduce the nuclear receptor superfamily and discuss the current literature on their effects on AMD-related pathophysiology.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, google, scholar, article, cas, agerelated, macular, degeneration, ophthalmol, central, sci, retinal, receptor, vis, eye, pigment, invest, arch, study, human, cells, receptors, res, nuclear, factor, choroidal, risk, epithelial, disease, drusen, ophthalmology, usa, amd, complement, reticular, maculopathy, retina, expression, exp, mol, cell, seddon, proc, natl, acad, lipid, association, genet, inflammation, neovascularization,

Topics {✒️}

peroxisome proliferator-activated receptor-gamma month download article/chapter peroxisome proliferator-activated receptors peroxisome proliferator-activated receptor oxidative stress-induced death photoreceptor/retinal pigment epithelium/bruch age-related ocular diseases age-related macular degeneration age-related macular degeneration age-related retinal degeneration incident age-related cataracts late-onset retinal degeneration glucocorticoid-receptor-mediated transactivation anti-amyloid therapy protects blood-derived macrophages infiltrate central nervous system trans-retinal dimer series early age-related maculopathy tnf-alpha-induced angiogenesis choroidal neovascular membranes seddon jm genome-wide association study full article pdf retinal pigment epithelium exudative macular degeneration retinoic acid receptor estrogen receptor-beta estrogen receptor alpha age-related maculopathy macular diseases optical coherence tomography experimental choroidal neovascularization simplified severity scale article malek geographic atrophy dexamethasone induced proliferation privacy choices/manage cookies beta amyloid assemblies ppar nuclear receptors age-related bruch nuclear receptor coactivators nuclear receptor atlas retinal dha levels immune-mediated processes orphan takes control epithelial-mesenchymal transition transcription factors article cellular related subjects health-related quality

Questions {❓}

Canfield AE et al (2007) HtrA1: a novel regulator of physiological and pathological matrix mineralization?
Van Leeuwen R et al (2004) Cholesterol and age-related macular degeneration: is there a link?

Schema {🗺️}

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         description:Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly in the Western world. Over the last 30 years, our understanding of the pathogenesis of the disease has grown exponentially thanks to the results of countless epidemiology, genetic, histological, and biochemical studies. This information, in turn, has led to the identification of multiple biologic pathways potentially involved in development and progression of AMD, including but not limited to inflammation, lipid and extracellular matrix dysregulation, and angiogenesis. Nuclear receptors are a superfamily of transcription factors that have been shown to regulate many of the pathogenic pathways linked with AMD and as such they are emerging as promising targets for therapeutic intervention. In this review, we will present the fundamental phenotypic features of AMD and discuss our current understanding of the pathobiological disease mechanisms. We will introduce the nuclear receptor superfamily and discuss the current literature on their effects on AMD-related pathophysiology.
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      description:Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly in the Western world. Over the last 30 years, our understanding of the pathogenesis of the disease has grown exponentially thanks to the results of countless epidemiology, genetic, histological, and biochemical studies. This information, in turn, has led to the identification of multiple biologic pathways potentially involved in development and progression of AMD, including but not limited to inflammation, lipid and extracellular matrix dysregulation, and angiogenesis. Nuclear receptors are a superfamily of transcription factors that have been shown to regulate many of the pathogenic pathways linked with AMD and as such they are emerging as promising targets for therapeutic intervention. In this review, we will present the fundamental phenotypic features of AMD and discuss our current understanding of the pathobiological disease mechanisms. We will introduce the nuclear receptor superfamily and discuss the current literature on their effects on AMD-related pathophysiology.
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         Cell Biology
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