
DOI . ORG {
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Title[redir]:
Vitamin D Receptor Polymorphisms and Cancer | SpringerLink
Description:
It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. In fact It has been hypothesized that polymorphisms in the VDR gene affect cancer risk and the relevance of...
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Keywords {π}
cancer, vitamin, chapter, polymorphisms, vdr, skin, receptor, risk, privacy, cookies, content, publish, sara, fok, bsm, springer, data, information, search, gandini, studies, taq, carcinoma, preview, download, personal, log, journal, research, sunlight, gnagnarella, serrano, pasquali, raimondi, gene, reported, access, article, author, ebook, make, optional, media, including, parties, european, policy, find, track, online,
Topics {βοΈ}
springer science+business media month download article/chapter privacy choices/manage cookies receptor gene variations gastric cancer risk renal cell carcinoma device instant download conditions privacy policy european economic area accepting optional cookies download preview pdf receptor genetic polymorphisms main content log sara gandini journal finder publish cancer risk author correspondence chapter usdΒ 29 patrizia gnagnarella davide serrano including cancer privacy policy check access ethics access chapter gandini cancer chapter chapter sunlight skin cancer affiliations division permissions reprints books a chapter cite optional cookies vdr polymorphisms social media manage preferences plasma levels chapter log personal data thyroid carcinoma hepatocellular carcinoma ovarian cancer bladder cancer cancer sites cancer prevention pasquali raimondi vdr genotype receptor polymorphisms essential cookies
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ScholarlyArticle:
headline:Vitamin D Receptor Polymorphisms and Cancer
pageEnd:105
pageStart:69
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-0437-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Sunlight, Vitamin D and Skin Cancer
isbn:
978-1-4939-0437-2
978-1-4939-0436-5
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Sara Gandini
affiliation:
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Patrizia Gnagnarella
affiliation:
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
type:Person
name:Davide Serrano
affiliation:
name:European Institute of Oncology
address:
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
type:PostalAddress
type:Organization
type:Person
name:Elena Pasquali
affiliation:
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
type:Person
name:Sara Raimondi
affiliation:
name:European Institute of Oncology
address:
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
type:PostalAddress
type:Organization
type:Person
keywords:Breast Cancer Risk, Thyroid Carcinoma, Skin Cancer, Oral Squamous Cell Carcinoma, Basal Cell Carcinoma
description:It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. In fact It has been hypothesized that polymorphisms in the VDR gene affect cancer risk and the relevance of VDR gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. However, results from previous studies on the association of VDR polymorphisms with different cancer types are somewhat contradictory, and the role of VDR in the etiology of cancer is still equivocal. We have performed a systematic review of the literature to analyze the relevance of more VDR polymorphisms (Fok1, Bsm1, Taq1, Apa1, and Cdx2) for individual malignancies, including cancer of the skin (melanomaand nonmelanoma skin cancer), ovarian cancer, renal cell carcinoma, bladder cancer, non-Hodgkin lymphoma, leukemia, thyroid carcinoma, esophageal adenocarcinoma, hepatocellular carcinoma, sarcoma, head and neck and oral squamous cell carcinoma. Up to June 2012, we identified 79 independent studies for a total of 52427 cases and 62225 controls. Significant associations with VDR polymorphisms have been reported for prostate (Fok1, Bsm1, Taq1), breast {Fok1, Bsm1, Apa1), colon-rectum (Fok1, Bsm1, Taq1) and skin cancer (Fok1, Bsm1, Taq1). Very few studies reported risk estimates for the other cancer sites. Conflicting data have been reported for most malignancies and at present it is still not possible to make any definitive statements about the importance of the VDR genotype for cancer risk. It seems probable that interactions with other factors such as calcium and vitamin D intake, 25(OH)D plasma levels and UV radiation exposure play a decisive role in cancer risk.
datePublished:2014
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Book:
name:Sunlight, Vitamin D and Skin Cancer
isbn:
978-1-4939-0437-2
978-1-4939-0436-5
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name:Springer New York
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url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
name:European Institute of Oncology
address:
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
type:PostalAddress
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
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Person:
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address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
email:[email protected]
name:Patrizia Gnagnarella
affiliation:
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
name:Davide Serrano
affiliation:
name:European Institute of Oncology
address:
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
type:PostalAddress
type:Organization
name:Elena Pasquali
affiliation:
name:Division of Epidemiology and Biostatistics
address:
name:Division of Epidemiology and Biostatistics, Milan, Italy
type:PostalAddress
type:Organization
name:Sara Raimondi
affiliation:
name:European Institute of Oncology
address:
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
type:PostalAddress
type:Organization
PostalAddress:
name:Division of Epidemiology and Biostatistics, Milan, Italy
name:Division of Epidemiology and Biostatistics, Milan, Italy
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
name:Division of Epidemiology and Biostatistics, Milan, Italy
name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
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