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Title:
Vitamin D Receptor Polymorphisms and Cancer | SpringerLink
Description:
It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. In fact It has been hypothesized that polymorphisms in the VDR gene affect cancer risk and the relevance of...
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Keywords {🔍}

cancer, vitamin, chapter, polymorphisms, vdr, skin, receptor, risk, privacy, cookies, content, publish, sara, fok, bsm, springer, data, information, search, gandini, studies, taq, carcinoma, preview, download, personal, log, journal, research, sunlight, gnagnarella, serrano, pasquali, raimondi, gene, reported, access, article, author, ebook, make, optional, media, including, parties, european, policy, find, track, online,

Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Vitamin D Receptor Polymorphisms and Cancer
      pageEnd:105
      pageStart:69
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-0437-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Sunlight, Vitamin D and Skin Cancer
         isbn:
            978-1-4939-0437-2
            978-1-4939-0436-5
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sara Gandini
            affiliation:
                  name:Division of Epidemiology and Biostatistics
                  address:
                     name:Division of Epidemiology and Biostatistics, Milan, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Patrizia Gnagnarella
            affiliation:
                  name:Division of Epidemiology and Biostatistics
                  address:
                     name:Division of Epidemiology and Biostatistics, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Davide Serrano
            affiliation:
                  name:European Institute of Oncology
                  address:
                     name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Elena Pasquali
            affiliation:
                  name:Division of Epidemiology and Biostatistics
                  address:
                     name:Division of Epidemiology and Biostatistics, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sara Raimondi
            affiliation:
                  name:European Institute of Oncology
                  address:
                     name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Breast Cancer Risk, Thyroid Carcinoma, Skin Cancer, Oral Squamous Cell Carcinoma, Basal Cell Carcinoma
      description:It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. In fact It has been hypothesized that polymorphisms in the VDR gene affect cancer risk and the relevance of VDR gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. However, results from previous studies on the association of VDR polymorphisms with different cancer types are somewhat contradictory, and the role of VDR in the etiology of cancer is still equivocal. We have performed a systematic review of the literature to analyze the relevance of more VDR polymorphisms (Fok1, Bsm1, Taq1, Apa1, and Cdx2) for individual malignancies, including cancer of the skin (melanomaand nonmelanoma skin cancer), ovarian cancer, renal cell carcinoma, bladder cancer, non-Hodgkin lymphoma, leukemia, thyroid carcinoma, esophageal adenocarcinoma, hepatocellular carcinoma, sarcoma, head and neck and oral squamous cell carcinoma. Up to June 2012, we identified 79 independent studies for a total of 52427 cases and 62225 controls. Significant associations with VDR polymorphisms have been reported for prostate (Fok1, Bsm1, Taq1), breast {Fok1, Bsm1, Apa1), colon-rectum (Fok1, Bsm1, Taq1) and skin cancer (Fok1, Bsm1, Taq1). Very few studies reported risk estimates for the other cancer sites. Conflicting data have been reported for most malignancies and at present it is still not possible to make any definitive statements about the importance of the VDR genotype for cancer risk. It seems probable that interactions with other factors such as calcium and vitamin D intake, 25(OH)D plasma levels and UV radiation exposure play a decisive role in cancer risk.
      datePublished:2014
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Sunlight, Vitamin D and Skin Cancer
      isbn:
         978-1-4939-0437-2
         978-1-4939-0436-5
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Division of Epidemiology and Biostatistics
      address:
         name:Division of Epidemiology and Biostatistics, Milan, Italy
         type:PostalAddress
      name:Division of Epidemiology and Biostatistics
      address:
         name:Division of Epidemiology and Biostatistics, Milan, Italy
         type:PostalAddress
      name:European Institute of Oncology
      address:
         name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
         type:PostalAddress
      name:Division of Epidemiology and Biostatistics
      address:
         name:Division of Epidemiology and Biostatistics, Milan, Italy
         type:PostalAddress
      name:European Institute of Oncology
      address:
         name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sara Gandini
      affiliation:
            name:Division of Epidemiology and Biostatistics
            address:
               name:Division of Epidemiology and Biostatistics, Milan, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Patrizia Gnagnarella
      affiliation:
            name:Division of Epidemiology and Biostatistics
            address:
               name:Division of Epidemiology and Biostatistics, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Davide Serrano
      affiliation:
            name:European Institute of Oncology
            address:
               name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Elena Pasquali
      affiliation:
            name:Division of Epidemiology and Biostatistics
            address:
               name:Division of Epidemiology and Biostatistics, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Sara Raimondi
      affiliation:
            name:European Institute of Oncology
            address:
               name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Division of Epidemiology and Biostatistics, Milan, Italy
      name:Division of Epidemiology and Biostatistics, Milan, Italy
      name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
      name:Division of Epidemiology and Biostatistics, Milan, Italy
      name:Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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