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ScholarlyArticle:
      headline:Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation
      pageEnd:116
      pageStart:109
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4757-9613-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Cellular Peptidases in Immune Functions and Diseases
         isbn:
            978-1-4757-9613-1
            978-1-4757-9615-5
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Martin Hegen
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Junichi Kameoka
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rui-Ping Dong
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chikao Morimoto
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stuart F. Schlossman
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Tyrosine Phosphorylation, Adenosine Deaminase, Dipeptidyl Peptidase, Severe Combine Immunodeficiency Disease, Induce Tyrosine Phosphorylation
      description:1996 was the 10th anniversary of the establishment of the cluster of differentiation antigen, CD26 by the Second Workshop and Conference on Human Leukocyte Differentiation Antigens1. First described as a T cell activation antigen, CD26 was found to he strongly expressed on subsets of both activated CD4 and CD8 T cells2. Subsequent work showed the expression of CD26 on activated Nk cells, B cells and B cell lines and demonstrated CD26 expression on a variety of different cell types, most abundantly on epithelia of the intestine, prostate and the proximal tubuli of the kidneys3,4,5. Furthermore, it was demonstrated that CD26 possesses enzymatic activity, dipeptidyl peptidase IV (DPP IV; EC 3.4.14.5), in its extracellular domain4 and is identical to the previously described adenosine deaminase (ADA, EC 3.5.4.4) binding protein6,7. Recent studies indicate that CD26 plays a seminal role in T cell costimulation and may be involved in severe combined immunodeficiency and HIV infection 8,9.
      datePublished:1997
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Book:
      name:Cellular Peptidases in Immune Functions and Diseases
      isbn:
         978-1-4757-9613-1
         978-1-4757-9615-5
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Harvard Medical School
      address:
         name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Martin Hegen
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Junichi Kameoka
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Rui-Ping Dong
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Chikao Morimoto
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Stuart F. Schlossman
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
      name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
      name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
      name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
      name:Division of Tumor Immunology Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, USA
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