We are analyzing https://link.springer.com/article/10.1007/bf01246674.

Title:
Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene | Immunogenetics
Description:
CD26 is a lymphocyte cell surface antigen which is increased during T -cell activation and is also expressed in other tissues. It is an atypical serine protease belonging to the prolyl oligopeptidase family. CD26 has been implicated in a variety of biological functions including T-cell activation, cell-to-cell adhesion, and recently in HIV infection. This paper describes, through the isolation and partial sequencing of eight humanCD26 genomic clones, the first information on the genomic organization of the prolyl oligopeptidase family. We have established that the humanCD26 gene spans approximately 70 kilo-bases (kb) and contains 26 exons, ranging in size from 45 base pairs (bp) to 1.4 kb. The nucleotides that encode the serine recognition site (G-W-S-Y G) are split between two exons. This clearly distinguishes the genomic organization of the prolyl oligopeptidase family from that of the classical serine protease family. The 5
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Keywords {🔍}

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Topics {✒️}

tpa-modulated trans-acting factor solid-phase immobilized anti-1f7 phorbol ester-inducible genes growth hormone-releasing factor month download article/chapter anti-1f7 monoclonal antibody mouse dipeptidyl-peptidase iv lung-metastatic rat breast hemato-lymphoid cell lines nh2-terminal signal sequence activated human t-lymphocytes gene locus dpp4 surface protease involved transcription factor active article immunogenetics aims humancd26 genomic clones full article pdf privacy choices/manage cookies rat cd26 antigen eukaryotic transcriptional elements dipeptidyl peptidase iv active site residues humancd26 gene encodes human metallothionein gene human pim-1 gene gene expression landscape related subjects distantly related members cell activation antigen t-cell activation prolyl oligopeptidase family dipeptidyl aminopeptidase iv human n-myc nonclassical serine hydrolases human cell lines cell surface ectopeptidase proline-dependent structural serine recognition site genomic organization cell surface modulation european economic area g-w-s potential binding sites metabolize circulating substance distinct collagen receptors catalytic triad residues xaa-boropro dipeptides short-stalked protein t-cell function human cytotoxic lymphocytes

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         headline:Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene
         description:CD26 is a lymphocyte cell surface antigen which is increased during T -cell activation and is also expressed in other tissues. It is an atypical serine protease belonging to the prolyl oligopeptidase family. CD26 has been implicated in a variety of biological functions including T-cell activation, cell-to-cell adhesion, and recently in HIV infection. This paper describes, through the isolation and partial sequencing of eight humanCD26 genomic clones, the first information on the genomic organization of the prolyl oligopeptidase family. We have established that the humanCD26 gene spans approximately 70 kilo-bases (kb) and contains 26 exons, ranging in size from 45 base pairs (bp) to 1.4 kb. The nucleotides that encode the serine recognition site (G-W-S-Y G) are split between two exons. This clearly distinguishes the genomic organization of the prolyl oligopeptidase family from that of the classical serine protease family. The 5' flanking domain of theCD26 gene contains neither a TATA box nor a CAAT box, but a 300 by region extremely rich in C and G (72%) contains potential binding sites for several transcriptional factors. The humanCD26 gene encodes two messages sized at about 4.2 and 2.8 kb. These are both expressed at high levels in the placenta and kidney and at moderate levels in the lung and liver. Only the 4.2 kb mRNA was expressed at low levels in skeletal muscle, heart, brain, and pancreas. Fluorescence in situ hybridization on metaphase chromosome spreads located the humanCD26 gene to the long arm of chromosome 2(2q24.3).
         datePublished:
         dateModified:
         pageStart:331
         pageEnd:338
         sameAs:https://doi.org/10.1007/BF01246674
         keywords:
            Serine Protease
            Genomic Organization
            Human CD26
            Metaphase Chromosome
            Prolyl
            Immunology
            Human Genetics
            Gene Function
            Cell Biology
            Allergology
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      headline:Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene
      description:CD26 is a lymphocyte cell surface antigen which is increased during T -cell activation and is also expressed in other tissues. It is an atypical serine protease belonging to the prolyl oligopeptidase family. CD26 has been implicated in a variety of biological functions including T-cell activation, cell-to-cell adhesion, and recently in HIV infection. This paper describes, through the isolation and partial sequencing of eight humanCD26 genomic clones, the first information on the genomic organization of the prolyl oligopeptidase family. We have established that the humanCD26 gene spans approximately 70 kilo-bases (kb) and contains 26 exons, ranging in size from 45 base pairs (bp) to 1.4 kb. The nucleotides that encode the serine recognition site (G-W-S-Y G) are split between two exons. This clearly distinguishes the genomic organization of the prolyl oligopeptidase family from that of the classical serine protease family. The 5' flanking domain of theCD26 gene contains neither a TATA box nor a CAAT box, but a 300 by region extremely rich in C and G (72%) contains potential binding sites for several transcriptional factors. The humanCD26 gene encodes two messages sized at about 4.2 and 2.8 kb. These are both expressed at high levels in the placenta and kidney and at moderate levels in the lung and liver. Only the 4.2 kb mRNA was expressed at low levels in skeletal muscle, heart, brain, and pancreas. Fluorescence in situ hybridization on metaphase chromosome spreads located the humanCD26 gene to the long arm of chromosome 2(2q24.3).
      datePublished:
      dateModified:
      pageStart:331
      pageEnd:338
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      keywords:
         Serine Protease
         Genomic Organization
         Human CD26
         Metaphase Chromosome
         Prolyl
         Immunology
         Human Genetics
         Gene Function
         Cell Biology
         Allergology
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