
NCBI . NLM . NIH . GOV {
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Title[redir]:
Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer - PMC
Description:
Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations ...
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Keywords {🔍}
cancer, google, scholar, pubmed, doi, cells, pmc, article, free, apoptosis, cell, vitro, guggulsterone, protein, expression, treatment, kunnumakkara, potential, growth, nfκb, receptor, human, pathway, activation, breast, signaling, tumor, res, proteins, sethi, kinase, cancers, wightii, stat, bordoloi, inhibits, bcl, commiphora, reported, fxr, pharmacol, banik, diseases, suppression, mol, prevention, proliferation, carcinoma, aggarwal, studies,
Topics {✒️}
peroxisome proliferator-activated receptor-gamma suppressing akt/mtor/nf-κb signalling nf-kappab-regulated gene products c-jun nh2-terminal kinase c-jun n-terminal kinase plasma trimethylamine-n-oxide expression sensitive lc-ms/ms method akt/mtor/nf-κbsignaling cascade nf-kappab-regulated gene expression reversing tnf-α-induced activation ��ikk/iκb/nf-κb axisa p-gp atpase dose-dependently jak/stat pathway-mediated mucin4 nf-κb-regulated inflammatory cytokines smokeless tobacco/nicotine-induced expression nuclear factor-kappab ligand p-glycoprotein-mediated multidrug resistance mitogen-activated protein kinase hydrogen peroxide-induced cytotoxicity high-performance liquid chromatography uhplc-orbitrap mass spectrometer drug-free rat serum pmc beta search nf-κb/erk/mapk/akt/stat eukaryotic initiation factor-2α nuclear factor-κb ligand hypoxia-inducible factor 1alpha plc/prf/5r inhibit tgf-β-induced emt streptozotocin-induced memory deficits nf-κb signaling cascade blocking ikk/nf-κb signaling granulocyte colony-stimulating factor anti-apoptotic gene products targeting beta-catenin signaling estrogen-positive tumors resistant extracellular signal-regulated kinase reduces fa-induced lipotoxicity wnt β-catenin signaling wnt/β-catenin pathway cox-2/p-gp dependent pathway fa-induced tg accumulation nicotine-induced nf-κb bcl-2 homologous antagonist/killer guggulsterone inhibits nf-kappab nf-κb blockers gifted long-chain aliphatic tetrols ras-related protein rab-21 antiapoptotic gene products src-mediated cross-talk
Questions {❓}
- FBXW7 in cancer: what has been unraveled thus far?
- Inflammation, NF-κB, and chronic diseases: how are they linked?
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