
DOI . ORG {
}
Title[redir]:
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo | PNAS
Description:
p21CIP1/WAF1 is a downstream effector of tumor suppressors and functions as a cyclin-dependent kinase inhibitor to block cellular proliferation. Breast tumors may derive from self-renewing tumor-in...
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Keywords {🔍}
pcip, cells, cancer, fig, cell, stem, expression, twist, emt, crossref, pubmed, google, scholar, mammary, tumors, tumor, gene, center, cmyc, markers, jefferson, ras, epithelial, mesenchymal, mcfaras, mcfacmyc, view, analysis, articles, biology, breast, features, haras, genes, department, university, author, increased, mice, induced, mcfa, kimmel, thomas, philadelphia, article, human, transgenic, ecadherin, data, sirna,
Topics {✒️}
org/cgi/content/full/0910009106/dcsupplemental tgf-beta/smad gene targets lesser extent mcf10a-c-myc e-box binding site mcf10a-c-myc cells treated mcf10a-c-myc cells transduced mcf10a-c-myc-induced emt cd44+/cd24− mcf10a-ras cells social media facebook cyclin-dependent kinase inhibitor supporting information online mcf10a-c-myc transformed c-myc expression induced c-myc induce epithelial mcf10a-c-myc treated genome-wide expression profiles mammary-targeted ha-ras c-myc-induced tumorigenesis p18inkc-deficiency-dependent tumorigenesis c-myc-induced features ras-dependent cellular migration jan-willem van ittersum c-myc-induced tumors oncogene-induced mammary tumors mammary oncogene-induced tumors c-myc induce features c-myc mammary tumors mcf10a-c-myc cells p21cip1 attenuated ha-ras c-myc-induced emt hsc-long-term hscs normal mammary gland cd44+/cd24−/low cells mmtv-c-myc/p21cip−/− human mammary glands renewing tumor-initiating cells stem/progenitor cell properties c-myc-p21cip1−/− tumors mesenchymal marker n-cadherin protein microarray-based analysis e-cadherin promoter activity p21cip1-induced emt pathways epithelial mesenchymal transition mcf10a-ras cellular migration demonstrated p21cip1-repressed genes ha-ras enhanced expression promotes ras-tumor progression cell surface markers comparing p21cip1-regulated genes gene expression profiles
Questions {❓}
- H Peinado, D Olmeda, A Cano, Snail, Zeb and bHLH factors in tumor progression: An alliance against the epithelial phenotype?
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