
NCBI . NLM . NIH . GOV {
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Title[redir]:
Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression - PMC
Description:
Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate pathway. Besides being a precursor of steroid hormones, bile acid, and vitamin D, it is an essential structural component of cell membranes, is enriched in ...
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Keywords {🔍}
doi, cancer, pubmed, google, scholar, cholesterol, breast, pmc, article, free, cells, cell, lipid, vitamin, membrane, pathway, role, tumor, risk, clinical, res, mva, patients, levels, increased, studies, steroid, acid, drugs, expression, mol, receptor, synthesis, therapy, study, srebp, treatment, data, hormones, rafts, potential, biol, metastasis, zoledronic, metabolism, signaling, growth, survival, high, drug,
Topics {✒️}
cholesterol-depleting agent methyl-β-cyclodextrin signalling pathways ras/erk1/2/hif-1α muc1/icam-1/src signaling triad pi3k/akt/mtor signaling pathway activates akt-mtor pathway activating tgf-beta signaling long-chain fatty acyl-coenzyme high-density lipoprotein-cholesterol levels pi3k/akt/mtor axis niemann-pick c1 protein improved disease-free survival pmc beta search sterol-resistant mutants y298c rhoa/rock/hif-1α triple-negative breast cancer increase disease-free survival metal-organic frameworks nanoparticles microenvironment-induced immune suppression producing ldl-masked doxorubicin membrane detergent-resistant membrane pi3k-akt-mtorc1 axis cytotoxic t-cells infiltrate glucose-mediated n-glycosylation single cell-based approaches small water-soluble molecules early-stage breast cancer atp-binding cassette long-acting bisphosphonate drug muc1-mediated motility ldl-receptor mediated endocytosis ferroptosis-resistant cell state high-grade breast cancer g-protein coupled receptors enhanced anti-tumor immunity article/supplementary material bone mineral density sterol o-acyltransferase enzymes her2-negative breast cancer disease-free survival acat1 reduces ldl-induced single-nucleus rna sequencing functional sterol-sensing domain erk/hif-1 pathway inhibition phospholipid-remodeling enzyme lpcat3 dose- time-dependent manner hormone receptor-positive bc pi3k/akt signaling erk/hif pathway leading anti-tumor immune-response low-density lipoprotein
Questions {❓}
- Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?
- Targeting the PI3K Pathway in Cancer: Are We Making Headway?
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- Earnings of https://doi.org/10.1016/j.molcel.2010.06.022
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- Discover the revenue of https://doi.org/10.1016/j.cell.2018.11.011
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- Profit of https://doi.org/10.1002/ijc.23597
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- Get to know https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Mol%20Cell%20Biol&title=Membrane%20Lipids:%20Where%20They%20Are%20and%20How%20They%20Behave&author=G%20van%20Meer&author=DR%20Voelker&author=GW%20Feigenson&volume=9&issue=2&publication_year=2008&pmid=18216768&doi=10.1038/nrm2330&'s earnings
- Profit of https://doi.org/10.1016/S0006-3495(98)77632-5
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- Monthly income for https://doi.org/10.1529/biophysj.108.133744
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- https://doi.org/10.1038/s41388-021-01720-w's financial summary
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