
NCBI . NLM . NIH . GOV {
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Title[redir]:
Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators - PMC
Description:
Androgen deprivation therapy (ADT) is the mainstay regimen in patients with androgen-dependent prostate cancer (PCa). However, the selection of androgen-independent cancer cells leads to castrate resistant prostate cancer (CRPC). The aggressive ...
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Keywords {🔍}
doi, google, scholar, pubmed, cancer, prostate, pmc, article, free, cells, signaling, nrf, crpc, pca, oxidative, stress, androgen, progression, cell, therapeutic, redox, receptor, nfκb, transcription, expression, patients, ros, antioxidant, tumor, factor, therapy, resistance, activation, potent, deprivation, suppress, levels, treatment, role, effects, nuclear, protein, hormone, clinical, curcumin, shown, studies, phase, potential, inflammatory,
Topics {✒️}
ccaat/enhancer binding protein-beta ccat/enhancer-binding protein-beta ras/raf/mek/erk pathway pd-l1/nkg2d ligand levels bis-dehydroxy-curcumin triggers mitochondrial c-maf negatively regulates 27-hydroxycholesterol-induced cellular senescence il-6/jak/stat3/nf-κb signaling ctc-derived ar-v7 detection hormone-deprivation-induced oxidative stress il-6/jak/stat3 signalling axis nf-kappab/p65 antagonizes nrf2 high-risk prostate cancer-classification nf-κb-mediated inflammatory response pmc beta search antioxidants abrogate alpha-tocopherylquinone-mediated nf-kappab-regulated gene expression hif-2α drives metastasis castration-resistant prostate cancer gr glutathione s-transferase castrate-resistant prostate cancer mitogen activated-protein kinase castration-induced oxidative stress nk cell-mediated cytotoxicity transforming growth factor-beta1 tumor necrosis factor-alpha δ-tocotrienol induces apoptosis nuclear translocated nf-κb prevent protein-protein interactions acquired redox-signaling network /ebp-β dependent activation derivative cddo-methyl ester induced ros-mediated apoptosis androgen-independent prostate cancer hormone-refractory prostate cancer intra-tumoral androgen production decreasing tgf-β nf-κb transcription factor[210] targeting foxa1-mediated repression phosphatidylinositol 3-kinase/protein kinase wnt/β-catenin ros-induced mutagenic effects androgen-dependent prostate cancer enzalutamide-resistant prostate cancer small-cell lung cancer biochim biophys acta splice-variant ar-v7 nf-κb regulated genes anti-inflammatory signaling responses androgen axis-targeted therapies
Questions {❓}
- Diagnosis of prostate cancer with needle biopsy: should all cases be biopsied before treatment?
- Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells?
- Is there a therapeutic benefit of antioxidants in CRPC progression?
- Metastatic prostate cancer remains incurable, why?
- Should we increase GFR with Bardoxolone in Alport syndrome?
- Sulforaphane and other nutrigenomic Nrf2 activators: can the Clinician’s expectation be matched by the reality?
- The prospect of identifying resistance mechanisms for castrate-resistant prostate cancer using circulating tumor cells: is epithelial-to-mesenchymal transition a key player?
- Tumor-specific induction of the intrinsic apoptotic pathway-a new therapeutic option for advanced prostate cancer?
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