
DOI . ORG {
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Title[redir]:
A draft network of ligandâreceptor-mediated multicellular signalling in human | Nature Communications
Description:
Cell-to-cell communication across multiple cell types and tissues strictly governs proper functioning of metazoans and extensively relies on interactions between secreted ligands and cell-surface receptors. Herein, we present the first large-scale map of cell-to-cell communication between 144 human primary cell types. We reveal that most cells express tens to hundreds of ligands and receptors to create a highly connected signalling network through multiple ligandâreceptor paths. We also observe extensive autocrine signalling with approximately two-thirds of partners possibly interacting on the same cell type. We find that plasma membrane and secreted proteins have the highest cell-type specificity, they are evolutionarily younger than intracellular proteins, and that most receptors had evolved before their ligands. We provide an online tool to interactively query and visualize our networks and demonstrate how this tool can reveal novel cell-to-cell interactions with the prediction that mast cells signal to monoblastic lineages via the CSF1âCSF1R interacting pair. Cell-to-cell communication relies upon interactions between secreted ligands and cell surface receptors. Here, Ramilowski et al.present a draft cell-to-cell communication network based on expression of ligand-receptor pairs in 144 different human cell types.
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Keywords {đ}
cell, cells, ligands, receptors, article, pairs, proteins, google, scholar, data, signalling, expression, cas, types, receptor, ligandreceptor, supplementary, protein, primary, expressed, ligand, genes, gene, analysis, fig, human, set, tpm, nature, celltocell, communication, lineages, haematopoietic, age, secreted, levels, network, found, interactions, subcellular, number, enrichment, localization, interacting, pair, average, proteome, enriched, type, fantom,
Topics {âď¸}
nature portfolio org/pub/databases/uniprot/current_release/knowledgebase/proteomes/ privacy policy open source tools ch/download/protected/string_9_1/protein advertising io/connectome ligandâreceptor-mediated multicellular signalling open source software social media author edda kloppmann mannâwhitney u-test-adjusted healthy middle-aged fantom5 cage libraries p-podâs22 orthomcl23 clustering 0/ reprints ligand-dependent development pre-computed estimates based nature 444 nature 507 nature 509 nature middle panel shows mannâwhitney u-test drd4/bdnf gene-gene interaction correctly post-translationally modified cancer research trust cell-type-specific expression profiles rna-seq data sets lineage-specific growth factor cell-type-restricted expression profiles protein phosphorylation/modification terms capture spatial relationships58 influences t-cell accumulation ccr9 beta-chemokine receptor org/cgi-bin/hgnc_downloads cell-type-restricted expression showed jp/5/suppl/ramilowski_et_al_2015/data/ csf1âcsf1r ligandâreceptor pair fantom5 b-cell transcriptome early embryonic development public proteinâprotein interaction computational tools loctree3 jp/5/suppl/ramilowski_et_al_2015/vis jp/5/suppl/ramilowski_et_al_2015/vis/ proteinâprotein interaction networks cell-type-specific pm proteins libraries human protein-coding genes receptorâligand pairs form
Questions {â}
- The evolution of multicellularity: a minor major transition?
Schema {đşď¸}
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headline:A draft network of ligandâÂÂreceptor-mediated multicellular signalling in human
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