
NCBI . NLM . NIH . GOV {
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Title[redir]:
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimerโs disease - PMC
Description:
N6-methyladenosine (m6A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain. We show that m6A modification displays temporal and spatial dynamics during ...
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Keywords {๐}
doi, methylation, pubmed, genes, google, scholar, pmc, article, mrna, free, levels, brain, rna, fig, compared, weeks, mice, expression, transcripts, methylated, file, protein, mouse, additional, differentially, gene, disease, aging, utr, alzheimers, development, data, xfad, wang, neurodevelopment, role, sites, differential, week, show, human, table, alternative, regulation, zhang, showing, list, involved, analysis, liu,
Topics {โ๏ธ}
ubiquitin-positive tau-negative inclusions ร-actin house-keeping gene eye-specific gmr-gal4 driver /articles/dataset/m6a_a_lc-ms-ms/13356179 lc-ms/ms m6a data lc-ms/ms m6a quantification n6-methyladenosine-dependent regulation anti-n6-methyladenosine antibody rna n6-methyladenosine methyltransferase exploring deep-sequencing data intraneuronal beta-amyloid aggregates pmc beta search lc-ms/ms quantification similar tissue-specific methylation steady-state mrna levels pre-built reference file tissue-specific developmental processes lc-ms/ms confirmed lc/ms-ms poly facilitates hippocampus-dependent learning rna-seq data processing rna-seq data served replicate rna-seq data acknowledgments review history 5-hmc-mediated epigenetic dynamics supplementary information 13059_2020_2249_moesm1_esm happ/ps1 ad models neuron-cellular interactions early 28-cm-height plastic tubes performed deep rna-seq /ashafik1/shafik_et_al_codes/tree/main [75] hippocampus-specific methylation correlates surviving high-quality reads refined rip-seq protocol analyze merip-seq data spatial-specific m6a methylation nuclease-free water human hnrnp a2/b1 lc-ms/ms regulates mammalian spermatogenesis m6a_a_lc-ms-ms data availability statements affect aging-related pathways hypothalamus-specific methylation occurs n6-methyladenosine dynamics gov/geo/query/acc +โenriched mrna-seq libraries license information pmcid tissue-specific methylation protein-protein interactions
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