
NCBI . NLM . NIH . GOV {
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Title[redir]:
Increased RAB31 Expression in Cancer-Associated Fibroblasts Promotes Colon Cancer Progression Through HGF-MET Signaling - PMC
Description:
RAB family proteins participate in the dynamic regulation of cellular membrane compartments and are dysregulated in a variety of tumor types, which may alter the biological properties of cancer cells such as proliferation, migration, and invasion. ...
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Keywords {🔍}
rab, cancer, cells, cafs, doi, expression, pubmed, google, scholar, cell, pmc, article, rko, caf, migration, free, tumor, crc, hgf, colon, met, figure, medium, stromal, data, control, assay, results, culture, significantly, cms, progression, role, staining, stroma, factor, raboverexpressing, vector, fibroblasts, signaling, proteins, growth, tissue, primary, increased, transwell, found, metastasis, protein, patients,
Topics {✒️}
fcr-mediated pi3k/akt signaling pi3k/akt/bcl-2/bax pathway formalin-fixed paraffin-embedded tissues age-matched balbc/nude mice pathogen-free colony cages c-met-dependent gene expression caf-secreted migration-promoting factors mir-30c-2-3p regulates significantly decreased p-met ras-related protein rab-31 distant metastasis-free survival quantitative reverse-transcription pcr high-throughput proteomics integrated hgf/met signaling pathway anti-hgf polyclonal antibody activating hgf/met signaling cation-dependent mannose-6-phosphate endosome/lysosome degradation pathway induce epithelial–mesenchymal transition hgf-neutralizing antibody reaches c-met recruits icam-1 high-throughput screening based hgf/met-dependent manner pmc beta search high-risk stage ii igf-1/igf-1r signaling fibroblast-derived basic protein data availability statement p75 neurotrophin receptor enhanced migration-inducing ability colon cancer-derived cafs 2nd-generation lentiviral vector 00 rko-luciferase+caf25 egfp rab31-egfp fusion protein key tumor-promoting factor small-animal anesthesia system rab31-overexpressing caf cm kaplan–meier survival analysis rab-mediated vesicle trafficking caf-mediated migration late-stage colorectal cancer ethics statement 67 rko-luciferase+caf25 rab31 nationwide population-based study pi3k/akt signaling paracrine tgf-beta signalling studied caf-secreted factors modulates epithelial interactions rab31-egfp shows colocalization caf marker α-sma
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