
DOI . ORG {
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Title[redir]:
Tumor–stroma ratio predicts recurrence in patients with colon cancer treated with neoadjuvant chemotherapy | Acta Oncologica
Description:
Background: Neoadjuvant chemotherapy represents a new treatment approach to locally advanced colon cancer. The aim of this study was to analyze the ability of tumor–stroma ratio (TSR) to predict disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy. Material and methods: This study included 65 patients with colon cancer treated with neoadjuvant chemotherapy in a phase II trial. All patients were planned for three cycles of capecitabine and oxaliplatin before surgery. Hematoxylin and eosin stained tissue sections from surgically resected primary tumors were sampled and analyzed by conventional microscopy. Patients were divided into stroma-high (>50%, i.e. TSR low) and stroma-low (≤50%, i.e. TSR high) for the comparison with clinical data. Results: A low TSR was found in 47% of the surgically resected primary tumors and correlated to a significantly higher T- and N-category compared, to tumors with a high TSR (p < .01). A low TSR was also significantly associated with disease recurrence (p = .008), translating into significant differences in disease free survival (DFS) and overall survival, p < .002. The 5-year DFS rate for patients with a low TSR was 55%, compared to 94% in the group of patients with a high TSR. Conclusions: TSR assessed in the surgically resected primary tumor from patients with locally advanced colon cancer treated with neoadjuvant chemotherapy provides prognostic value and may serve as a relevant parameter in selecting patients for post-operative treatment.
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Keywords {🔍}
denmark, cancer, vejle, policy, patients, research, university, tsr, acta, oncologica, hospital, institute, danish, colorectal, center, south, regional, health, southern, odense, colon, neoadjuvant, chemotherapy, symposia, submission, treated, oncology, content, articles, recurrence, low, high, download, published, skip, make, open, data, review, tumorstroma, ratio, locally, advanced, disease, surgically, resected, primary, tumors, license, main,
Topics {✒️}
submission make cite frøstrup hansen downloads download data tumor–stroma ratio main content skip colon cancer treated submission direct kjær-frifeldt rafael rafaelsen henrik jensen brandt sørensen creative commons cc european cancer rehabilitation neoadjuvant chemotherapy represents acta oncologica predict disease recurrence precision medicine radiotherapy nordic signatures commits quality content clinical data regional health research phase ii trial author informa uk limited offer global reach sweden contact radiophysics psychosocial oncology post-operative treatment significantly higher t n-category compared 5-year dfs rate make disease free survival neoadjuvant chemotherapy disease recurrence stroma-high stroma-low cancer monthly newsletter aarhus university hospital southern denmark research contributions latest research 0 international license modern oncology denmark doi treatment approach lindebjerg jakobsen 1651-226x published
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