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Keywords {🔍}

ascorbate, dose, subjects, phase, pasch, doi, cancer, months, clinical, trial, radiation, survival, gbm, median, therapy, pharmacological, temozolomide, subject, rtphase, mgmt, google, scholar, adverse, events, free, promoter, pubmed, plasma, pmc, progression, grade, study, methylation, data, figure, treatment, tmz, article, adjuvant, adjphase, table, pfs, combined, safety, design, rttmz, cohort, toxicity, range, glioblastoma,

Topics {✒️}

org/professionals/physician_gls/pdf/cns intra-patient dose escalation conclusions p-asch−/rt/tmz concurrent rt/tmz/ p-asch− node-positive pancreatic cancer harmonisation—good clinical practice gov/newsevents/meetingsconferencesworkshops/ucm602540 pmc beta search enhance rt/tmz effectiveness data suggest p-asch− radio-chemo-therapy responses gov/drugsatfda_docs/label/2016/021029s031lbl estimate progression-free survival pre-defined radiographic checkpoints p-asch− dose cohorts standard rt/tmz regimen p-asch− dose cohort kaplan-meier curves primary gbm post-surgery clin cancer res p-asch− infusion fluid adj-phase evaluation period progression free survival standard rt/tmz therapy central nervous system plasma ascorbate concentrations defined rt-phase window [google scholar] 23 plasma ascorbate levels normal tissue injury protecting normal tissue cancer clinical trials chemotherapy induced toxicity interpatient dose escalation mgmt promoter methylation decreased neutrophil count neutrophil count decreased enhances tumor radiosensitization methylated mgmt promoter methylated mgmt promoter subsequent clinical trials anti-oxidant systemically dose limiting toxicities minimal toxicity relative complete blood count preclinical models iv ovarian cancer idh wild type plasma samples collected requiring inpatient admission

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