
NCBI . NLM . NIH . GOV {
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Title[redir]:
The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury - PMC
Description:
Sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) remains the leading complication for mortality caused by bacterial infection. The regulatory T (Treg) cells appear to be an important modulator in resolving lung ...
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Keywords {🔍}
lung, mice, hmgb, pten, tregs, injury, βcatenin, cells, doi, pubmed, google, scholar, cdcdfoxp, increased, tgfβ, expression, figure, signaling, treatment, pmc, lps, rhmgb, inflammatory, article, macrophages, cell, free, treg, ptenmko, response, myeloid, foxp, induction, controls, acute, βcateninmko, ptenflox, activation, analysis, cocultures, spleen, animal, data, samplesgroup, regulatory, macrophage, ali, βcateninflox, group, levels,
Topics {✒️}
hmgb1/pten/β-catenin signaling represents myeloid-specific pten/β-catenin knockout macrophage hmgb1/pten/β-catenin signaling receptor-mediated nf-kappab activation hmgb1/pten/β-catenin axis hmgb1/pten/β-catenin signaling tgf-beta-induced foxp3 inhibits myeloid-specific β-catenin ablation anti-mouse cd4-pe-cyanine5 producing cd4+cd25+foxp3+ tregs induces cd4+cd25+foxp3+ tregs foxp3-expressing cd4+cd25+ regulatory increased cd4+cd25+foxp3+ tregs cd4+cd25+foxp3+ tregs leading promoting β-catenin signaling reduced cd4+cd25+foxp3+ tregs anti-hmgb1 antibody-treated mice induce cd4+cd25+foxp3+ tregs inhibits pi3k/pdk1/akt leading increasing cd4+cd25+foxp3+ tregs myeloid-specific pten knockout myeloid β-catenin signaling specific pathogen-free conditions cd4+cd25+foxp3+ treg induction anti-hmgb1 antibody-instilled mice promoting β-catenin activation ptenm−ko/β-cateninm−ko affect β-catenin signaling cd4+cd25+foxp3+ tregs compared myeloid cell-specific pten β-catenin deficiency lost myeloid-specific knockout mice pmc beta search pten increased β-catenin activating nf-κb translocation promote β-catenin signaling pten/β-catenin loxp myeloid β-catenin resulted promotes β-catenin activation hmgb1-mediated inflammatory response decreases tgf-β release reduced tgf-β release suppressed β-catenin activity cd4+cd25+foxp3+ tregs cd4+cd25+foxp3 tregs cd4+cd25+foxp3+tregs generate β-cateninm−ko sepsis-driven inflammatory responses rhmgb1-treated ptenm−ko mice cd4+cd25+foxp3+ treg
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