
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial - PMC
Description:
This phase 2 randomized clinical trial assesses the safety and efficacy of durvalumab with and without tremelimumab for the treatment of patients with metastatic pancreatic ductal adenocarcinoma.
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Keywords {🔍}
doi, patients, therapy, google, scholar, pancreatic, pubmed, cancer, pmc, durvalumab, article, combination, free, part, tumor, monotherapy, study, arm, treatment, data, immune, tremelimumab, blockade, cells, adenocarcinoma, efficacy, response, checkpoint, mpdac, expression, randomized, trial, safety, pdl, pdac, ductal, phase, clinical, disease, months, patient, survival, metastatic, weeks, adverse, supplement, oncol, events, rate, cell,
Topics {✒️}
dual anti–pd-1/anti–ctla-4 blockade anti-programmed cell death-ligand-1 designate pd-l1–high expression pd-l1–low/negative expression support pd-l1/ctla-4 blockade anti–pd-1/pd-l1 mabs pd-l1–expressing tumor cells anti–programmed death–ligand 1 focal adhesion kinase human anticytotoxic t-lymphocyte active t-cell suppression pmc beta search phosphor-integrated dot staining paraffin-embedded tumor tissue myeloid-derived suppressor cells recurrent squamous-cell carcinoma small-cell lung cancer t-cell checkpoint immunotherapy pd-1/pd-l1 blockade anti–pd-l1 antibody evaluate pd-l1 expression tab pd-l1 expression anti–ctla-4 mab resulted key points question programmed death-ligand 1 late-stage clinical trials [google scholar] 13 treatment-related adverse events microsatellite instability–high status poor prognostic factor gemcitabine-based chemotherapy regimen primary end point progression-free survival full trial protocol combination immuno-oncology therapy dual checkpoint inhibition concurrent platinum-based chemotherapy t-cell activation anticytotoxic t-lymphocyte license information pmcid unacceptable toxic effects pd-l1–high gov/ftp1/ctcae/ctcae_4 pd-l1–low pd-l1 expression anti–pd-l1 /anti–pd-l1 anti–ctla-4 mabs metastatic pancreatic adenocarcinoma common adverse events
Questions {❓}
- Does combination immuno-oncology therapy (anti–programmed death–ligand 1 and anticytotoxic T-lymphocyte–associated antigen 4) provide clinical benefit for patients with metastatic pancreatic ductal adenocarcinoma?
- The stromal compartments in pancreatic cancer: are there any therapeutic targets?
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi