
NCBI . NLM . NIH . GOV {
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Title[redir]:
Queuine links translational control in eukaryotes to a micronutrient from bacteria - PMC
Description:
In eukaryotes, the wobble position of tRNA with a GUN anticodon is modified to the 7-deaza-guanosine derivative queuosine (Q34), but the original source of Q is bacterial, since Q is synthesized by eubacteria and salvaged by eukaryotes for ...
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Keywords {🔍}
codons, codon, modification, figure, pmtδ, translational, pubmed, google, scholar, doi, trna, pombe, translation, pmt, cells, pmc, article, methylation, trnas, free, genes, occupancy, ribosome, uending, supplementary, trnaasp, showed, effect, speed, mitochondrial, presence, absence, cending, data, asp, dnmt, rna, function, analysis, respective, effects, medium, activity, levels, misreading, relative, overexpression, mrnas, efficiency, acids,
Topics {✒️}
ortho-nitrophenyl-ß-d-galactopyranoside nutritional supplement fine-tunes specific pathogen-free conditions supplementary tables s6–s8 35s-marked amino acids pmc beta search high-throughput bisulfite sequencing feeder-free 2i medium high-throughput rna sequencing wild-type ß-galactosidase reverse-phase liquid chromatography wild-type amino acid amino-methyl side chain crispr-cas9 genome editing threonyl-carbamoyl-adenosine 7-deaza-guanosine derivative queuosine a-site codon occupancies dnmt2-dependent trna methylation benjamini–hochberg-adjusted p benjamini–hochberg adjusted p u-ending glycine codon u-ending gly codon anticodon–anticodon complexes showed dnmt2-dependent m5c38 methylation partially c38-methylated trnaasp coli β-galactosidase expressed ribosomal a-site occupancy accelerating c-ending codons dnmt2-dependent trnaasp methylation assigned a-site position intrinsic codon–anticodon strength mutant β-gal versions codon-anticodon pairing efficiencies translational speed transcriptome-wide respective u-ending codons u-ending codons differs ribosome-protected mrna fragments q-mediated error suppression germ-free mice genome-wide protein coding universal yrdc/sua5 family u-ending codon relative respective u-ending asp codon–anticodon mini-helix respective c-ending codons high-throughput sequencing affect codon–anticodon interaction weaker codon–anticodon interaction u-ending asp codon equally strongly q-modified
Questions {❓}
- Modify or die?
- Pombe relate to those in higher eukaryotes?
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