
NCBI . NLM . NIH . GOV {
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Title[redir]:
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity - PMC
Description:
A defining feature of adaptive immunity is the development of long-lived memory T cells to curtail infection. Recent studies have identified a unique stem-like T cell subset in exhausted CD8+ T cells in chronic infection1–3, but it remains unclear ...
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Keywords {🔍}
cells, data, fig, expression, extended, doi, cell, mice, analysis, yfp, gene, rptorilacre, pubmed, google, scholar, pmc, genes, article, mog, memory, free, dln, day, tcf, tbet, rreyfp, raptordeficient, metabolic, mtorc, enrichment, genotype, regions, flow, atacseq, pseudotime, cytometry, cxcr, performed, signatures, samples, test, experiments, reads, differentiation, open, numbers, sets, binding, motif, nucleosomefree,
Topics {✒️}
srebp-dependent rate-limiting enzyme nucleosome-free atac-seq tracks reduced tcf-1lot-bethi population terminally-differentiated cd27−t-bethi increased tcf-1hit-betlo finalized nucleosome-free regions specific pathogen-free conditions tcf-lef family factors exclusively tcf-1lot-bethi pan-acetyl histone bound reciprocal cd27−t-bethi subset myelin oligodendrocyte glycoprotein-specific tcf-1lot-bethi subset pmc beta search tcf-1lot-bethi population cd27− cd4+tcrβ+yfp+ cells counted nucleosome-free reads transcription factor t-bet prolonged interleukin-2ralpha expression cd4+tcrβ+yfp+ cells stimulated generate gene-cell matrices highlights mtorc1-dependent shaping �cd25lo memory-precursor cd8” rna-seq read counts single cell rna-sequencing short-lived th17 cells superimposing atac-seq results pipeline performed de-multiplexing tcf-1 chip-seq peaks cell-dependent iga responses successful anti-cancer therapy freshly-isolated yfp+ cells tcrβ+yfp+cd44hicd27− cells cd4+cd25−cd62l+cd44− single-cell mrna quantification t-bet binding sites predominantly raptor-deficient cells t-bet binding motifs drugs targeting 4e-bp expressing mog antigen-specific antigen-specific memory cd8+ cd27+tcf-1hi subset il-23-induced stat3 phosphorylation lef/tcf-1 family tcf-lef family nucleosome free region nucleosome-free reads m-values normalization method scrna-seq data alignment raptor-deficient th17 cells
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