
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity - PMC
Description:
Regulatory T cells (Tregs) protect cancer cells from immune attack. Tregs express CD25 on their surface and can be killed by antibodies and immunoconjugates targeting CD25. These agents have not been effective in controlling tumor growth, probably ...
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Keywords {π}
cells, tumor, tumors, epe, doi, tregs, mice, fig, pubmed, google, scholar, cell, treatment, cancer, injected, antitumor, immune, injection, immunotoxin, antibody, depletion, pmc, regulatory, article, ctm, anticd, immunity, number, mouse, local, free, activity, therapy, growth, appendix, increased, untreated, immunol, systemic, cytotoxic, effect, rit, targeting, kill, days, regressions, activated, left, responses, produced,
Topics {βοΈ}
il-2βdependent cd25-expressing mouse cd3+cd4+cd25+foxp3+ tregs tsk gel-filtration chromatography agonistic anti-ox40 antibody org/lookup/suppl/doi anti-mouse igg-hrp pmc beta search anti-mouse cd25 antibody renal tracerx consortium recombinant anti-mesothelin immunotoxin anti-mouse cd8a antibody potent anti-cd25 immunotoxin long-lasting regressions immunotoxin-targeting human mesothelin melanoma tracerx consortium pc61 anti-cd25 antibody cd4+foxp3+ treg cells anti-human mesothelin rit cells producing ifn-gamma fc-dependent depletion interleukin-2 receptor alpha cd4+cd25+foxp3+ tregs kill cd25-expressing cells cd11b+ ly6gβ cd11clow/neg tumor-infiltrating foxp3+ regulatory anti-pe antibody ip12 anti-cd25 antibody treatment potent cell-killing activity cell-dependent antitumor effect cells expressing ifn-Ξ³ cd25 blockade depletes cd25-positive line induces antitumor immunity anti-mouse cd25 cd25-negative line anti-cd8 antibody combined injected anti-cd8 antibody anti-mouse antibodies shown supplementary materials included 2e4-pe38-e553d inactive mutant nearby immune-suppressor cells anti-ctla-4 therapy mouse cd25 protein producing systemic toxicity partially depletes tregs mesothelin-expressing mesothelioma anti-cd25 antibody ct26m colon cancer 66c14 breast cancer analyzed tumor-infiltrating lymphocytes
Questions {β}
- Do suppressor T cells exist?
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- How much does https://www.nlm.nih.gov/careers/careers.html net monthly?
- What's the income of https://www.nlm.nih.gov/?
- Financial intake of https://www.nih.gov/
- How much revenue does https://www.hhs.gov/ produce monthly?
- How much profit does https://www.usa.gov/ make?
Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {π}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {π¦}
- Ncbi