
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding - PMC
Description:
Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin ...
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Keywords {🔍}
binding, enhancers, fig, sites, google, scholar, doi, pubmed, supplemental, enhancer, pmc, article, chromatin, time, free, model, dex, accessibility, motif, expression, gene, cell, data, dynamics, change, occupancy, factor, genomic, genes, initial, motifs, activation, exposure, increased, test, results, genome, tfs, distal, chipseq, histone, glucocorticoid, transcription, strength, factors, log, dhss, decreased, human, sets,
Topics {✒️}
granulocyte-macrophage colony-stimulating factor lineage-determining transcription factors feed-forward transcriptional programming input-subtracted chip-seq data input-subtracted chip-seq signal protein-coding gene tsss pmc beta search [doi] [pubmed] [google scholar] stratified fivefold cross-validation supplemental tables s1–s4 long-lasting gr binding motif-directed binding ian vivo protein–dna interactions control-subtracted chip-seq protein-coding gene features motif-directed binding drives feed-forward circuitry cell type-specific enhancers additional motif-directed binding python package scikit-learn pre-dex dnase-seq single factor-bound sites enhancer dynamics thereon—depend /duke-gcb/ggr-cwl gc-responsive enhancer dynamics supplementary materials included pre-dex tf occupancy dex-responsive activity dynamics ctcf-bound preaccessible dhss gc-triggered dynamic activity motif-driven gr binding references arnold cd cell division–related terms dex-responsive expression dynamics classify dex-responsive enhancers initial dnase-seq abundance heatmaps show dnase-seq gr chip-seq peaks enhances glucocorticoid action initial dnase-seq signal org/cgi/doi/10 enhancer-driven gr binding 3-kb tss-proximal region gc-induced enhancer activity high-throughput studies cell-type-specific pre-dex time point post-dex time point signal-dependent transcription factors
Questions {❓}
- How do glucocorticoids influence stress responses?
- Transcriptional enhancers: intelligent enhanceosomes or flexible billboards?
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