
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mutations in RNA methylating enzymes in disease - PMC
Description:
RNA methylation is an abundant modification identified in various RNA species in both prokaryotic and eukaryotic organisms. However, the functional roles for the majority of these methylations remain largely unclear. In eukaryotes, many RNA ...
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Keywords {🔍}
doi, rna, google, scholar, pubmed, methylation, pmc, article, free, mutations, resistance, enzymes, rrna, nsun, methylating, trna, antibiotic, ribosomal, methyltransferase, methylations, mrna, mettl, modification, cancer, biol, identified, lossoffunction, human, mutation, loss, cell, disease, substrate, eukaryotic, modifications, nucleotide, mitochondrial, rlmn, trnas, intellectual, mol, nat, site, chem, prokaryotic, mechanism, binding, table, lack, enzyme,
Topics {✒️}
s-adenosyl-l-methionine s-adenosylmethionine-dependent methyltransferases er-negative breast cancer post-transcriptional gene regulation transcriptome-wide mapping revealed pmc beta search enzyme-mediated conjugate addition full-length nsun3 lead cri-du-chat syndrome [27] cri-du-chat syndrome low-level antibiotic resistance tlya-encoded 2′-o-methylations aminoglycoside-resistance methyltransferase npma confer high-level resistance abundant post-transcriptional modifications autosomal-recessive intellectual disability linezolid-resistant cons isolates post-transcriptional nucleotide modification curr opin oncol streptomycin-resistant clinical isolates n6-methyladenosine-encoded epitranscriptomics x-ray crystal structure n6-methyladenosine-dependent regulation [google scholar] 34 trmt61b-mediated methylation plays rlmaii-mediated rrna methylations nsun family members low-level resistance modified nucleoside n-2-methylguanosine confers moderate resistance trmt1-catalyzed trna modifications specific nsun2-mediated methylation disease-induced cellular alterations low abundant rnas electrophilic methyl group dynamic n1-methyladenosine methylome nat chem biol license information pmcid rna methylating enzymes substrate radical intermediate rrma gene encoding dominant negative proteins nat rev microbiol broad groups based identify key mediators ribosomal subunit interfaces thermophilus ksga mutant endonucleolytic cleavage resulting multicomponent methyltransferase complex 30s ribosomal subunit
Questions {❓}
- What do we know about ribosomal RNA methylation in Escherichia coli?
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