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Keywords {🔍}

mbd, atpb, copper, domain, doi, google, scholar, pubmed, protein, mbds, atox, domains, interactions, activity, data, atpase, pmc, transfer, binding, nterminal, fig, peptide, free, article, nmr, group, disease, regulation, metalbinding, residues, structure, chemical, biol, atoxcu, dynamics, shift, lutsenko, mechanism, chem, wilson, membrane, conformation, mbdmbd, saxs, chaperone, cell, open, site, metal, human,

Topics {✒️}

phosphine ddm n-dodecyl-β-d-maltoside 1% n-dodecyl-β-d-maltoside x-ray scattering data small-angle scattering data low atox1–cu/apo–atox1 ratios small-angle scattering atox1–cu/apo–atox1 ratio increase n-terminal metal-binding sites copper-transporting pib-type atpase x-ray structure n-terminal copper-binding sites atp7b-bound strep-tactin resin n-terminal copper-binding domain atox1–cu/apo–atox1 ratio apo–atox1/atox1–cu ratio n-terminal cytoplasmic tail fourth metal-binding domain atox1–cu–mbd intermediate pmc beta search c-terminal strep-tag 50 mm tris-hcl cu-dependent anterograde traffic performed n-terminal sequencing pmc copyright notice direct domain–domain contacts apo–atox1 specifically binds regulatory n-terminal domain laemmli sds-page metal-binding domain chain distinct nucleotide-binding environment author contributions metal-binding domains regulates copper-binding sites determine supplementary materials included platinum-based anticancer drugs formed copper-bridged adducts domain nucleotide-binding domain menkes copper-transporting atpase single unit human copper-transporting atpases metal-free atox1 total protein/data point apo–atox1 removes copper atp7b cu-atpase mediate 1 atox1/mbd ratio rat copper-transporting atpase cu-gsh activated atp7b copper-binding cxxc motifs top-scoring cluster wilson disease-causing mutations

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