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Title[redir]:
The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients | Tumor Biology
Description:
This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total of 338 Chinese Han lung cancer patients were enrolled in this study. All patients underwent at least two cycles of platinum-based chemotherapy. Four tag SNPs of ATP7B (rs1061472, rs9535826, rs7999812, and rs9535828) were selected to evaluate their impacts to platinum-based chemotherapy in these patients. ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients. Patients with A allele in ATP7B rs9535828 presented an increased susceptibility to platinum drugs (OR 1.96, 95 % CI 1.17–3.30, p < 0.01). Patients with G allele in ATP7B rs9535826 had the highest susceptibility to platinum drugs (OR 2.05, 95 % CI 1.19–3.52, p < 0.01). Our findings suggest that ATP7B genetic polymorphisms could affect the therapeutic efficacy of platinum-based chemotherapy, and ATP7B gene might be considered as predictive markers for the efficacy evaluation of platinum-based chemotherapy in Chinese Han lung cancer patients.
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article, pubmed, google, scholar, cancer, cas, atpb, patients, lung, chemotherapy, copper, platinumbased, resistance, cisplatin, cell, central, zhou, platinum, genetic, yin, china, analysis, polymorphisms, clinical, chinese, res, research, safaei, transporter, disease, privacy, cookies, content, wang, gong, chen, liu, access, nonsmall, biochem, protein, biol, carcinoma, human, university, data, publish, search, tumor, xiangping,
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zhi-cheng gong & bo-ting zhou platinum-based cancer chemotherapy month download article/chapter ji-ye yin nccn small cell maldi-tof mass spectrometry lung cancer patients zhao-qian liu soluble metal-binding domain human copper-transporting atpases atp7b genetic polymorphism high-performance dna analysis platinum-based chemotherapy bo-ting zhou atp7b genetic polymorphisms full article pdf national cancer institute zhi-cheng gong central south university japanese cancer patients cell culture models lung cancer ovarian carcinoma cells genetic polymorphism hunan provincial science biochem cell biol natl cancer inst privacy choices/manage cookies nat rev cancer cancer metastasis rev human endometrial carcinoma author information authors urothelial bladder cancer cu-transporting atpase clin cancer res assoc cancer res national high-tech therapeutic efficacy affiliated cancer hospital metal binding domains chen-yue qian genetic polymorphisms check access instant access copper transporter atp7b hunan key laboratory wei-jing gong reversing platinum resistance platinum anticancer drugs article li
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headline:The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients
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Cancer Research
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description:This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total of 338 Chinese Han lung cancer patients were enrolled in this study. All patients underwent at least two cycles of platinum-based chemotherapy. Four tag SNPs of ATP7B (rs1061472, rs9535826, rs7999812, and rs9535828) were selected to evaluate their impacts to platinum-based chemotherapy in these patients. ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients. Patients with A allele in ATP7B rs9535828 presented an increased susceptibility to platinum drugs (OR 1.96, 95 % CI 1.17–3.30, p < 0.01). Patients with G allele in ATP7B rs9535826 had the highest susceptibility to platinum drugs (OR 2.05, 95 % CI 1.19–3.52, p < 0.01). Our findings suggest that ATP7B genetic polymorphisms could affect the therapeutic efficacy of platinum-based chemotherapy, and ATP7B gene might be considered as predictive markers for the efficacy evaluation of platinum-based chemotherapy in Chinese Han lung cancer patients.
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Cancer Research
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email:[email protected]
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name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
name:Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, People’s Republic of China
name:Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
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