NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC5642494/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC5642494/. The analysis below is for the second page.
Title[redir]:
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer - PMC
Description:
Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) metastatic breast cancer in clinical trials. Here, we examined the ...
Title[redir]:
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer - PMC
Description:
Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) metastatic breast cancer in clinical trials. Here, we examined the ...
Matching Content Categories {π}
- Science
- Health & Fitness
- Education
Content Management System {π}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 6,399,052 visitors per month in the current month.
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How Does Ncbi.nlm.nih.gov Make Money? {πΈ}
We can't see how the site brings in money.
Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Ncbi.nlm.nih.gov has a revenue plan, but it's either invisible or we haven't found it.
Keywords {π}
abemaciclib, cells, cell, cdk, cancer, treatment, breast, treated, figure, doi, mcf, inhibition, supplementary, observed, senescence, lines, positive, google, scholar, tumor, data, expression, pubmed, dmso, days, activity, inhibitor, proliferation, cycle, Ξ²gal, phosphorylation, decrease, apoptosis, cat, hours, pmc, led, efm, mdamb, staining, day, growth, cyclin, concentrations, number, foxm, additional, control, vehicle, consistent,
Topics {βοΈ}
cdk4/cdk6/cyclind/rb/p16ink4a pathway plays goat anti-chicken igy dose-dependent anti-tumor activity multiparametric cell-based assay cell-free biochemical assays anti-Ξ²-galactosidase antibody pmc beta search vivo anti-tumor activity vitro cell-free assays c-terminal domain repeat c-terminal repeat domain detectable Ξ²-gal increased hormone receptor positive 3-methyl-2-oxo-8-quinolin-3-yl-2 annexin v-fitc kit neu-induced breast tumorigenesis biomarkers included phosphor-rb specific d-type cyclins er+ breast cancer Ξ²-gal positive cells cdk6/cyclin d3 complexes full chemical names metastatic breast cancer pi3k/mtor inhibitor bez235 increased Ξ²-gal staining er+ cell lines supplementary materials oncotarget-08-69493-s001 increased Ξ²-gal expression supplementary figure 1bβ1d anti-foxm1 antibody breast cancer models supplementary figure 2aβ2d high-content imaging Ξ²-gal levels decreased tumor-bearing mice estrogen receptor positive c-terminal domain relative ec50 values hr+ breast cancer cell-based assays abemaciclib induces concentration-dependent nod scid mice apoptosis occurred earlier cdk4/cyclin d1 complexes license information pmcid multi-site phosphorylation [8] untreated mda-mb-361 cells breast cancer proliferation hr- cell lines hr+ cell lines
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