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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://www.nature.com/articles/35082500, but it redirected us to https://www.nature.com/articles/35082500. The analysis below is for the second page.

Title[redir]:
Specific protection against breast cancers by cyclin D1 ablation | Nature
Description:
Breast cancer is the most common malignancy among women. Most of these cancers overexpress cyclin D1, a component of the core cell-cycle machinery. We previously generated mice lacking cyclin D1 using gene targeting. Here we report that these cyclin D1-deficient mice are resistant to breast cancers induced by the neu and ras oncogenes. However, animals lacking cyclin D1 remain fully sensitive to other oncogenic pathways of the mammary epithelium, such as those driven by c-myc or Wnt-1. Our analyses revealed that, in mammary epithelial cells, the Neu–Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolute dependency on cyclin D1 for malignant transformation in this tissue. Our results suggest that an anti-cyclin D1 therapy might be highly specific in treating human breast cancers with activated Neu–Ras pathways.

Matching Content Categories {📚}

  • Education
  • Telecommunications
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, cyclin, cas, google, scholar, cancer, nature, breast, cell, access, mice, content, mammary, pathway, genes, cookies, sicinski, oncogene, biol, privacy, cancers, ras, human, open, expression, transgenic, data, specific, geng, gene, cells, transformation, activated, cdk, overexpression, pubmed, development, leder, research, advertising, protection, information, journal, subscribe, piotr, lacking, targeting, neu, institution, buy,

Topics {✒️}

nature portfolio permissions reprints research progress privacy policy advertising g1/s-promoting mechanism parallel social media nature med author information authors yan geng & piotr sicinski core cell-cycle machinery mammary gland development nature 369 nature 398 nature 384 nature 411 nature dana-farber cancer institute mmtv/v-ha-ras author correspondence beta-catenin regulates expression pbabe-puro-ras-v12 fsh-responsive gene involved cyclin d1-deficient mice dfci/harvard medical school mmtv/c-myc genes anti-cyclin d1 therapy beta-casein gene expression e2f-dependent signaling pathway personal data springerlink instant access data protection cell-cycle machinery permissions activated neu–ras pathways human breast cancer breast cancer therapy mammary epithelial cells activated c-neu oncogene breast cancer detected cyclin d1 ablation hc11 cell line harvard medical school privacy development situ breast carcinomas gonadal cell proliferation ras signaling pathway cyclin d1 expression p38/hogmapk pathway

Questions {❓}

  • Are all cancer genes equal?

Schema {🗺️}

WebPage:
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         headline:Specific protection against breast cancers by cyclin D1 ablation
         description:Breast cancer is the most common malignancy among women. Most of these cancers overexpress cyclin D1, a component of the core cell-cycle machinery. We previously generated mice lacking cyclin D1 using gene targeting. Here we report that these cyclin D1-deficient mice are resistant to breast cancers induced by the neu and ras oncogenes. However, animals lacking cyclin D1 remain fully sensitive to other oncogenic pathways of the mammary epithelium, such as those driven by c-myc or Wnt-1. Our analyses revealed that, in mammary epithelial cells, the Neu–Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolute dependency on cyclin D1 for malignant transformation in this tissue. Our results suggest that an anti-cyclin D1 therapy might be highly specific in treating human breast cancers with activated Neu–Ras pathways.
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      headline:Specific protection against breast cancers by cyclin D1 ablation
      description:Breast cancer is the most common malignancy among women. Most of these cancers overexpress cyclin D1, a component of the core cell-cycle machinery. We previously generated mice lacking cyclin D1 using gene targeting. Here we report that these cyclin D1-deficient mice are resistant to breast cancers induced by the neu and ras oncogenes. However, animals lacking cyclin D1 remain fully sensitive to other oncogenic pathways of the mammary epithelium, such as those driven by c-myc or Wnt-1. Our analyses revealed that, in mammary epithelial cells, the Neu–Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolute dependency on cyclin D1 for malignant transformation in this tissue. Our results suggest that an anti-cyclin D1 therapy might be highly specific in treating human breast cancers with activated Neu–Ras pathways.
      datePublished:
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      name:Piotr Sicinski
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            name:Dana-Farber Cancer Institute, Harvard Medical School
            address:
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Social Networks {👍}(2)

External Links {🔗}(182)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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