
NCBI . NLM . NIH . GOV {
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Title[redir]:
GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation - PMC
Description:
1,25-dihydroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promising therapy for acute myeloid leukemia (AML) based on its ability to drive differentiation of leukemic cells. However, clinical trials have ...
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Keywords {🔍}
gsk, cells, aml, inhibition, differentiation, doi, vdr, combination, pubmed, google, scholar, activity, cell, fig, leukemia, treated, pmc, treatment, phosphorylation, signaling, article, jnk, growth, lithium, analysis, hours, cancer, kinase, regimen, leads, human, free, transcriptional, assay, dmediated, clinical, receptor, performed, study, inhibitor, enhances, myeloid, effects, low, studies, nmoll, ability, addition, activation, nbt,
Topics {✒️}
relative quantitative rt-pcr pmc beta search mh100×4-tk-luc plasmids trans retinoic acid real-time pcr phospho-ser208 vdr antibody gsk3β-deficient aml cells 25d-mediated anticancer activity fda-approved gsk3 inhibitor retinoic acid receptors constitutively active kinase gsk3-mediated inhibitory phosphorylation 25d-mediated differentiation reinforcing western blot analysis acute promyelocytic leukemia enhance differentiation-based therapy vdre-luciferase [kindly provided 25d-mediated growth inhibition acute myeloid leukemia 25d-mediated aml differentiation vitro kinase assays multi-tasking kinase advanced solid tumors superoxide-generating system established gsk3 inhibitors chemical gsk3 inhibitors fda-approved agent p-c-jun increasing transcriptional activity license information pmcid updated human knowledge casein kinase ii specific gsk3 inhibitors high-dose oral calcitriol publisher site pdf cell-cycle status myeloid leukemia cells rapidly dividing cells human promyelocyticleukemia cells packaging plasmids pcmvδr8 quantitate myeloid differentiation pathway analysis showed nuclear hormone 1alpha vdr transcriptional activity wnt/beta-catenin enhanced avian rt irreversible growth arrest circulating human aml rar-mediated differentiation enhance growth inhibition
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