Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Wordpress Themes And Plugins
  7. Keywords
  8. Topics
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091231, but it redirected us to https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091231. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Background Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on the prognosis of human non-small cell lung cancer (NSCLC) and the effects of GSK3β inhibition in NSCLC cell lines. Methods Immunohistochemical and western blot assays were used to evaluate the GSK3β expression level in human NSCLC tissues. Lentiviral RNA interference was performed to inhibit the expression of GSK3β in the A549, H292, H1299 and SK-MES-1 cell lines. Cell survival, apoptosis and motility were evaluated in vivo and in vitro. Results The levels of GSK3β were greater in NSCLC tissues (n = 211) than in control tissues (n = 194) (P<0.001). The 5-year follow-up analysis showed that positive GSK3β expression was indicative of poor prognosis (P = 0.006). Furthermore, knockdown of GSK3β in NSCLC cell lines suppressed cell proliferation, arrested tumor cells in G0/G1 phase, induced apoptosis and reduced cell motility. A xenograft model showed that the deregulation of GSK3β attenuated tumorigenesis, as confirmed by reduced cell proliferation based on Ki-67 and significantly increased apoptotic cell death. The inhibition of GSK3β had inconsistent effects on the expression of β-catenin, depending on the cell type examined. Conclusion Aberrant expression of GSK3β serves as an independent marker of poor prognosis for NSCLC. The inhibition of GSK3β suppressed tumorigenesis by attenuating cell proliferation, increasing apoptosis and restraining cell motility. These results identify GSK3β as a tumor promoter and a potential therapeutic target in NSCLC.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?


Doi.org is powered by WORDPRESS. But there are also traces of other content systems on the page (hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be cashing in, but we can't detect the method they're using.

Wordpress Themes and Plugins {🎨}

What WordPress theme does this site use?

It is strange but we were not able to detect any theme on the page.

What WordPress plugins does this website use?

It is strange but we were not able to detect any plugins on the page.

Keywords {🔍}

gskβ, cell, cells, cancer, nsclc, expression, tumor, article, view, google, scholar, inhibition, results, survival, lung, group, proliferation, glycogen, apoptosis, synthase, tissues, figure, analysis, lines, kinase, data, patients, prognosis, study, positive, plos, βcatenin, protein, image, xenograft, tumors, mice, levels, shown, significantly, apoptotic, human, target, role, demonstrated, normal, rna, vitro, control, transfection,

Topics {✒️}

health guidelines cookies plos plos cyclic-amp-dependent protein kinase open-access article distributed contributed reagents/materials/analysis tools glycogen synthase kinase-3/factor complex diseases glycogen synthase kinase-3beta original author zxq bjc hx worldwide cancer-related deaths plsd post-hoc test fluorescence-activated cell sorting colorectal cancer [12] colorectal cancer c-jun/ap-1 signaling interrupting e2f-dna interaction nf-κb expression levels specific pathogen-free conditions glycogen synthase kinase-3 nuclear factor-kappab cell-type specific manner balb/c-nu/nu sk-mes-1 cell lines jz dl zxq phosphorylated glycogen synthase paired normal/tumor tissues dark brown staining paraffin-embedded xenograft tumors barely detectable staining real-time rt-pcr real-time quantitative pcr prostate cancer [30] prostate cancer inhibit cell death apoptotic cells/total number wml jz dl jz dl yh pgcsil-gfp lentiviral vector squamous cell cancer a549 cell line image shows representative image colorectal [12] cell counting kit-8 cell signaling technology multi-tasking kinase squamous cell carcinoma

Social Networks {👍}(3)

External Links {🔗}(170)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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