
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of the macrophage activation syndrome: Re-analysis of a prior Phase III trial - PMC
Description:
To determine the efficacy of anakinra (recombinant interleukin-1 receptor antagonist) in improving 28-day survival in sepsis patients with features of macrophage activation syndrome (MAS). Despite equivocal results in sepsis trials, anakinra is ...
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Keywords {🔍}
doi, patients, anakinra, sepsis, pubmed, google, scholar, treatment, syndrome, study, hbddic, mas, placebo, receptor, dic, severe, hbd, mortality, survival, day, activation, trial, group, interleukin, macrophage, dysfunction, clinical, pmc, med, analysis, groups, features, phase, antagonist, data, shock, death, nonhbddic, article, hemophagocytic, variables, aki, blood, received, crit, care, drug, hbddicpositive, iii, randomized,
Topics {✒️}
�multi-organ dysfunction syndrome” hbd-positive/placebo group begins hbd/dic-positive patients stratified groups including hbd/dic-positive original open-label trial severe sepsis share macrophage activation syndrome �macrophage activation syndrome” hbd/dic-positive placebo treated glycosylated human il-1ra il-1β signal transduction hlh/sepsis/sirs/mods/mas secondary hemophagocytic syndrome secondary hemophagocytic lymphohistiocytosis hbd/dic-positive treatment group pmc beta search kaplan-meier survival estimates comparing pre-treatment variables acute-phase response severe organ dysfunction placebo-controlled multicenter trial end organ dysfunction multi-colinearity test found organ dysfunction [hbd excessive inflammatory response reactive hemophagocytic lymphohistiocytosis reactive hemophagocytic syndrome previously termed secondary methods data source interleukin-1 receptor antagonist hbd/dic-positive patients observed favorable response elevated macrophage expression confirmatory statistical evaluations contributor information macrophage serum markers acute kidney injury hbd-positive/anakinra group hbd/dic patients randomized preliminary diagnostic guidelines shared clinical/laboratory features il-1 receptor antagonist license information pmcid phase iii human leukocytic pyrogen acute brain dysfunction short half-life publisher site pdf hbd/dic group subjects higher-dose anakinra
Questions {❓}
- See editorial "IL-1 receptor antagonist in sepsis: new findings with old data?
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