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Title[redir]:
Pediatric Critical Care Medicine
Description:
ing eight diagnostic criteria needed to be met: 1) fever, 2) cytopenia of two lines, 3) hypertriglyceridemia and/or hypofibrinogenemia, 4) hyperferritinemia (>500 μg/L), 5) hemophagocytosis, 6) elevated soluble interleukin-2 receptor (CD25), 7) decreased natural killer-cell activity, and 8) splenomegaly can also commonly be found in patients with sepsis, systemic inflammatory response syndrome (SIRS), multiorgan dysfunction syndrome (MODS), and macrophage activation syndrome (MAS). Nevertheless, the therapeutic options for these are radically different. Chemotherapy and bone marrow transplant have been used for treatment of HLH/SHLH, whereas antibiotics and supportive treatment are used in severe sepsis/SIRS and MODS. MAS is treated with limited immune suppression. Outcomes are also different, SHLH has a mortality rate around 50%, whereas pediatric septic shock and MODS have a mortality of 10.3% and 18%, respectively, and severe sepsis in previously healthy children has a mortality rate of 2%. MAS has a mortality rate between 8% and 22%. Because SHLH and severe sepsis/SIRS/MODS/MAS share clinical and laboratory inflammatory phenotypes, we recommend extreme caution when considering applying HLH therapies to children with sepsis/SIRS/MODS/MAS. HLH therapies are clearly warranted for children with HLH; however, a quantitative functional estimate of cytotoxic lymphocyte function may be a more precise approach to define the overlap of these conditions, better identify these processes, and develop novel therapeutic protocols that may lead to improved treatments and outcomes....
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Keywords {🔍}
critical, care, journal, pediatric, medicine, children, hlh, international, sepsis, issue, severe, syndrome, society, mortality, access, log, subscribe, alerts, secondary, articles, authors, abstract, share, hemophagocytic, lymphohistiocytosis, inflammatory, shlh, mods, mas, rate, sccm, register, logo, issues, collections, member, permissions, response, dysfunction, activation, phenotypes, buy, diagnostic, criteria, therapeutic, treatment, outcomes, septic, sepsissirsmodsmas, therapies,
Topics {✒️}
multiorgan dysfunction syndrome macrophage activation syndrome critical care medicine laboratory inflammatory phenotypes secondary hemophagocytic lymphohistiocytosis critical care societies severe sepsis/sirs sepsis/sirs/mods/mas severe sepsis 0b013e3181a1ae08 buy abstract institutional users access authors journal info individual subscribers log access log pediatric septic shock journal authors submit hemophagocytic lymphohistiocytosis etoc alerts attain earlier diagnoses longer differentiate primary bone marrow transplant limited immune suppression recommend extreme caution quantitative functional estimate cytotoxic lymphocyte function sccm credentials primetime flexible bronchoscopy extracorporeal membrane oxygenation artificial intelligence training international histiocyte society diagnostic criteria needed previously healthy children international guidelines journal tables pediatric intensive issue applying hlh therapies register subscribe leticia md service request 800-638-3030 journal diagnostic criteria sepsis website subscribe center submit 2009the society hlh therapies inflammation castillo therapeutic options precise approach
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