
NCBI . NLM . NIH . GOV {
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Title[redir]:
Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer - PMC
Description:
Tamoxifen is an effective anti-estrogen treatment for patients with estrogen receptor-positive (ER+) breast cancer, however, tamoxifen resistance is frequently observed. To elucidate the underlying molecular mechanisms of tamoxifen resistance, we ...
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Keywords {🔍}
tamr, expression, cell, doi, tamoxifen, mirnas, cancer, breast, lines, mirna, google, scholar, pubmed, resistance, cells, line, mirb, figure, growth, mcfs, pmc, gene, analysis, patients, article, observed, snai, showed, free, tamoxifenresistant, regulation, altered, functional, qpcr, target, mira, targets, signaling, genes, data, mrnas, supplementary, treatment, identified, foxm, predicted, study, significant, rna, pathways,
Topics {✒️}
standard phenol-red-free dmem mirna-mrna inverse-correlation list computationally-predicted mirna-target pairs er/epha2-positive breast cancer mirna-mediated post-transcriptional regulation tamoxifen-sensitive subline mcf-7/s0 hormone-resistant breast cancer estrogen receptor alpha-positive wilcoxon rank-sum test tamoxifen-resistant breast cancer lna-based qpcr assay cancer-related signaling pathways correlated mirna-mrna pairs robust multi-array average inferred mirna-target relationships predicted mirna-target pairs predicted mirna-target relationships analyze mirna-mediated regulation computationally-identified mrna targets functional mirna-gene relationship mirna-mrna expression profiles mirna-mediated gene regulation probe-level quantile-normalization tamoxifen-resistant cell lines protein-protein interaction information pmc beta search functional mirna-target relationships ecm-receptor signaling pathways anti-estrogenic drugs differ tumor-infiltrated lymph nodes derived mirna-target pairs real time pcr mir-33b/fyn axis observed log-transformed normalized values identified mirna-target relationships mir-29b mir-516a-5p sirna-mediated gene knockdown pp2-mediated growth inhibition mirna-mediated tamoxifen resistance tamoxifen-resistant tumor growth patient-level meta-analysis protein synthesis induced individual resistant clones tamoxifen-sensitive mcf-7/s0 src family kinases lna-based qpcr mirna log2-fold small rna-seq analysis modulate mir-135a expression gn25-mediated growth inhibition
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