
NCBI . NLM . NIH . GOV {
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Title[redir]:
miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway - PMC
Description:
Epithelial–mesenchymal transition (EMT) and Notch signaling are important for the growth and invasion of pancreatic cancer, which is a leading cause of cancer-related deaths worldwide. miR-34a has been shown to play pivotal roles in the progression ...
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Keywords {🔍}
mira, cancer, notch, cell, pancreatic, snail, cells, expression, doi, pubmed, google, scholar, gene, pmc, signaling, fig, mimics, invasion, inhibitors, article, emt, apoptosis, free, protein, control, migration, levels, lines, panc, overexpression, target, tumor, ecadherin, transfection, growth, inhibits, transition, results, proliferation, supplementary, effects, demonstrated, transcription, decreased, performed, sites, epithelialmesenchymal, genes, program, mimic,
Topics {✒️}
wnt1-mta1-β-catenin axis10 snail1-induced epithelial-mesenchymal transition jak-stat3-snail signaling pathway snail1-mediated epithelial–mesenchymal transition serum-free culture medium pmc beta search mir-34a mimic-treated group microrna-34a dependent manner dmem high-glucose medium high-glucose dmem medium notch1 regulates mir-34a snail1-induced partial epithelial inducing epithelial-mesenchymal transition multi-level notch/su double-negative feedback loop epithelial marker e-cadherin37 formulated mir-34a mimics circulating mir-34a level elevated mir-34a level cancer-related deaths worldwide low mir-34a expression mir-34a inhibitors enhanced mir-34a expression increased mir-34a treated group tgf-β-mediated emt mir-34a binding sites mir-34a expression levels mir-34a inhibitors increased decreased mir-34a levels mir-34a mimics decreased post-transcriptionally regulating snail1 mir-34a regulates rt-pcr results demonstrate caspase-dependent pathways epithelial–mesenchymal transition epithelial-mesenchymal transition inhibited cell growth supplementary figs s1 cell-type dependent pancreatic cancer processes snail1-mediated emt program inhibited cell growth12 mir-34a inhibited mutant reporter plasmids notch signaling pathway epithelial-mesenchymal transitions epithelial-mesenchymal plasticity cancer cell growth license information pmcid discussion mir-34a
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