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  6. Keywords
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We began analyzing https://link.springer.com/article/10.1007/s00216-012-6226-x, but it redirected us to https://link.springer.com/article/10.1007/s00216-012-6226-x. The analysis below is for the second page.

Title[redir]:
Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery | Analytical and Bioanalytical Chemistry
Description:
Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators, are (non-) enzymatically generated by oxidation of polyunsaturated fatty acids such as arachidonic acid (AA). A plethora of lipid mediators exist which makes the development of generic analytical methods challenging. Here we developed a robust and sensitive targeted analysis platform for oxylipins and applied it in a biological setting, using high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) operated in dynamic multiple reaction monitoring (dMRM). Besides the well-described AA metabolites, oxylipins derived from linoleic acid, dihomo-γ-linolenic acid, α-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid were included. Our comprehensive platform allows the quantitative evaluation of approximately 100 oxylipins down to low nanomolar levels. Applicability of the analytical platform was demonstrated by analyzing plasma samples of patients undergoing cardiac surgery. Altered levels of some of the oxylipins, especially in certain monohydroxy fatty acids such as 12-HETE and 12-HEPE, were observed in samples collected before and 24 h after cardiac surgery. These findings indicate that this generic oxylipin profiling platform can be applied broadly to study these highly bioactive compounds in relation to human disease.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,420 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

google, scholar, article, cas, oxylipins, acid, surgery, human, levels, compounds, metabolites, plasma, acids, fig, derived, prostaglandins, lipid, mass, oxylipin, analysis, lox, cardiac, hete, liquid, spectrometry, eicosanoids, detection, patients, table, platform, min, fatty, high, samples, detected, matrix, van, inflammation, arachidonic, mrm, performed, method, level, analytical, lcmsms, observed, related, pufas, time, netherlands,

Topics {✒️}

comprehensive lc-ms/ms analysis liquid chromatography-mass spectrometric numerous lc-ms/ms methods 6-trans-ltb4/6-trans-12-epi ltb4 improved lc-ms/ms method generic lc-ms/ms platform gas chromatography–mass spectrometry tandem mass spectrometry lc-ms/ms chromatogram lc-ms/ms analysis residual double-bond number poly-unsaturated fatty acids lc-ms/ms method triple quadrupole system hplc-ms/ms approach circadian rhythm-dependent cycling high-throughput protein quantitation related hydroxy-fatty acids dihomo-γ-linolenic acid cyp epoxygenase-dependent metabolism van der greef user-defined time segments full size image ischemic-reperfused rat hearts epa-derived hydroxypentaenoic acids 14-dihydro-15-keto-pgf1α/1a netherlands metabolomics centre anti-inflammatory lipid mediators electronic supplementary material hplc-ms/ms ischemic/reperfused cardiac tissue gas chromatography coupled article download pdf 6-keto-pgf1α change rapidly substantial inter-patient variation la-derived hydroxyoctadecadienoic acids 100 nm 1-cyclohexyluriedo-3-dodecanoic acid electronic supplementary materials liquid chromatography privacy choices/manage cookies lox-dependent products include multiple reaction monitoring mass hunter quan monohydroxy fatty acids 19-hydroxy-pgf2α/20-hydroxy-pgf2α bioanalytical chemistry aims ltb4/12-epi ltb4 aa-derived hydroxyeicosatetraenoic acids john van duynhoven myocardial ischemia/reperfusion injury

Schema {🗺️}

WebPage:
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         headline:Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery
         description:Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators, are (non-) enzymatically generated by oxidation of polyunsaturated fatty acids such as arachidonic acid (AA). A plethora of lipid mediators exist which makes the development of generic analytical methods challenging. Here we developed a robust and sensitive targeted analysis platform for oxylipins and applied it in a biological setting, using high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) operated in dynamic multiple reaction monitoring (dMRM). Besides the well-described AA metabolites, oxylipins derived from linoleic acid, dihomo-γ-linolenic acid, α-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid were included. Our comprehensive platform allows the quantitative evaluation of approximately 100 oxylipins down to low nanomolar levels. Applicability of the analytical platform was demonstrated by analyzing plasma samples of patients undergoing cardiac surgery. Altered levels of some of the oxylipins, especially in certain monohydroxy fatty acids such as 12-HETE and 12-HEPE, were observed in samples collected before and 24 h after cardiac surgery. These findings indicate that this generic oxylipin profiling platform can be applied broadly to study these highly bioactive compounds in relation to human disease.
         datePublished:2012-07-20T00:00:00Z
         dateModified:2012-07-20T00:00:00Z
         pageStart:1413
         pageEnd:1426
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            12-HEPE
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            Characterization and Evaluation of Materials
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ScholarlyArticle:
      headline:Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery
      description:Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators, are (non-) enzymatically generated by oxidation of polyunsaturated fatty acids such as arachidonic acid (AA). A plethora of lipid mediators exist which makes the development of generic analytical methods challenging. Here we developed a robust and sensitive targeted analysis platform for oxylipins and applied it in a biological setting, using high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) operated in dynamic multiple reaction monitoring (dMRM). Besides the well-described AA metabolites, oxylipins derived from linoleic acid, dihomo-γ-linolenic acid, α-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid were included. Our comprehensive platform allows the quantitative evaluation of approximately 100 oxylipins down to low nanomolar levels. Applicability of the analytical platform was demonstrated by analyzing plasma samples of patients undergoing cardiac surgery. Altered levels of some of the oxylipins, especially in certain monohydroxy fatty acids such as 12-HETE and 12-HEPE, were observed in samples collected before and 24 h after cardiac surgery. These findings indicate that this generic oxylipin profiling platform can be applied broadly to study these highly bioactive compounds in relation to human disease.
      datePublished:2012-07-20T00:00:00Z
      dateModified:2012-07-20T00:00:00Z
      pageStart:1413
      pageEnd:1426
      license:https://creativecommons.org/licenses/by/2.0
      sameAs:https://doi.org/10.1007/s00216-012-6226-x
      keywords:
         HPLC-MS/MS
         dMRM
         12-HETE
         12-HEPE
         Analytical Chemistry
         Biochemistry
         general
         Laboratory Medicine
         Characterization and Evaluation of Materials
         Food Science
         Monitoring/Environmental Analysis
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      author:
            name:Katrin Strassburg
            affiliation:
                  name:Leiden Amsterdam Centre for Drug Research, Leiden University
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                  name:Netherlands Metabolomics Centre
                  address:
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            name:Kirsten A. Kortekaas
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                  address:
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            name:Jan H. Lindeman
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                  name:Leiden University Medical Center
                  address:
                     name:Department of General Surgery, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
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            name:Theresa L. Pedersen
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            name:Adrie Dane
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                  name:Leiden Amsterdam Centre for Drug Research, Leiden University
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                     name:Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, The Netherlands
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                     name:Netherlands Metabolomics Centre, Leiden, The Netherlands
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                  name:Leiden Amsterdam Centre for Drug Research, Leiden University
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