
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer - PMC
Description:
Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ...
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Keywords {🔍}
fibroblasts, cells, figure, tumor, cisplatin, ifnγ, cancer, gsh, doi, ovarian, cell, medium, platinum, resistance, xct, fibroblast, intracellular, stromal, apoptosis, treatment, patients, pubmed, google, scholar, cysteine, cystine, cisplatininduced, effect, content, pmc, figures, expression, response, dna, article, survival, found, increased, level, mice, treated, cultured, chemoresistance, free, high, reduced, data, levels, measured, gas,
Topics {✒️}
liquid chromatography-mass spectrometry cd8+ t-cell-derived interferon real-time pcr assays upregulating caf-derived versican pmc beta search full-length xct promoter fibroblast-derived small molecule dna double-strand break abrogate stromal-mediated chemoresistance sup1 nihms776369-supplement-sup1 sup2 nihms776369-supplement-sup2 gamma-glutamyl cycle present fibroblast-mediated tumor protection fibroblast-mediated platinum resistance real-time pcr quantification cell-derived ifnγ abolishes fibroblast-mediated cisplatin resistance promoted cisplatin-induced apoptosis inhibited cisplatin-induced apoptosis references binder dc platinum-based drugs remain dna damage-mediated apoptosis fibroblast-induced platinum resistance cisplatin-dna adduct formation ifnγ-induced stat1 phosphorylation experimental time period fibroblast-induced cisplatin resistance cell-derived ifnγ abolished cell-derived supernatants abolished anti-human ifnγ antibody ifnγ-activated stat1 binds cisplatin-induced tumor apoptosis reversed ifnγ-mediated downregulation including ovarian cancer atp-dependent efflux decreased 14c-cystine uptake fibroblasts confer cisplatin-resistance supplementary materials included xct pre-mrna level promotes tumor growth γ-cys-glu concentrations cisplatin-treated mice injected cisplatin-induced γh2ax expression transcription start site epithelial ovarian cancer quantified α-sma+ fibroblasts b7-h1 elevate intracellular gsh license information pmcid fibroblast-mediated chemoresistance
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