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Title[redir]:
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data - PMC
Description:
Summary: Advances in high-throughput sequencing technologies now allow for large-scale characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic diversity of the Ig repertoire presents challenges for biologically ...
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Keywords {π}
google, scholar, changeo, repertoire, pmc, doi, analysis, pubmed, sequencing, immunoglobulin, data, article, diversity, tools, free, shm, cell, sequences, nlm, germline, alleles, lineage, models, yaari, highthroughput, methods, immunol, information, somatic, utilities, selection, mutations, ncbi, search, gene, clonal, trees, sequence, stern, based, package, national, largescale, repertoires, suite, analyses, variable, individual, hypermutation, file,
Topics {βοΈ}
hot/cold-spot targeting models high-throughput sequencing technologies high-throughput sequencing technology [google scholar] gadala-maria human b-cell repertoire tab-delimited text file pmc beta search error-prone repair pathways exponential shannon-weiner index [google scholar] felsenstein [google scholar] robins creating lineage trees [google scholar] kleinstein simple tab-delimited file gene segment alleles analysis tasks changeo-clt repertoire sequencing experiments 6203114 [google scholar] united states government publisher site pdf generating lineage trees sequence records assignment large-scale characterization human immunoglobulin repertoire large datasets generated somatic hypermutation targeting analyzing large-scale clonally related sequences web server issue immunoglobulin genotype elucidation cell lineage information error-corrected reads ig lineage tree varying sequencing depth published somatic hypermutation clonal tree data house analysis pipelines repertoire sequencing toolkit lymphocyte receptor repertoires individual ig genotype germline alleles personalized complex analysis tasks cell trafficking patterns pmc disclaimer biologically meaningful analysis clonal groups calculation reordering analysis steps clonal group sizes measuring repertoire diversity assess repertoire diversity
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