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Keywords {🔍}

lefranc, google, scholar, imgt, article, pubmed, cas, analysis, giudicelli, cell, immunoglobulin, immunogenetics, receptor, information, imgtvquest, duroux, system, sequences, gene, chapter, nucleic, acids, res, montpellier, protocol, vdj, standardized, imgthighvquest, tool, antibody, receptors, genes, chaume, international, kaas, nomenclature, privacy, cookies, content, data, publish, tools, nucleotide, online, access, sequence, immunology, eds, imgtontology, database,

Topics {✒️}

imgt/v-quest integrates imgt/junctionanalysis antigen receptors-high-throughput version month download article/chapter standardized sequence-structure representations formal imgt-ontology paradigm imgt/v-quest identifies marie-paule lefranc colliers de perles imgt® home page high-throughput version privacy choices/manage cookies nova science publishers yousfi-monod imgt/highv-quest high-throughput system national transplant services device instant download rio de janeiro antigen receptors represents v-region mutations imgt/v-quest 13th international congress ighv gene insertions imgt unique numbering wolters kluwer health author information authors editor information editors cell receptors report imgt standardized criteria gene-centered information imgt® immunoinformatics tools adaptive immune response disease-related situations imgt reference directory hot spot positions integrated software program imgt/3dstructure-db imgt/structural query imgt® received funding région languedoc-roussillon cell receptor v immunogenetics sequence annotation imgt/gene-db imgt gene identification journal finder publish conditions privacy policy tr standardized v imgt® ­standardized analysis chronic lymphocytic leukemia royal melbourne hospital

Questions {❓}

• Kaas Q, Ehrenmann F, Lefranc M-P (2007) IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?

Schema {🗺️}

ScholarlyArticle:
      headline:IMGT® Tools for the Nucleotide Analysis of Immunoglobulin (IG) and T Cell Receptor (TR) V-(D)-J Repertoires, Polymorphisms, and IG Mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
      pageEnd:604
      pageStart:569
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-61779-842-9.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Immunogenetics
         isbn:
            978-1-61779-842-9
            978-1-61779-841-2
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Eltaf Alamyar
            affiliation:
                  name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
                  address:
                     name:IMGT®, the International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patrice Duroux
            affiliation:
                  name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
                  address:
                     name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-Paule Lefranc
            affiliation:
                  name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142
                  address:
                     name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142, Montpellier, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Véronique Giudicelli
            affiliation:
                  name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
                  address:
                     name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:IMGT, Immunogenetics, Immunoinformatics, Immunoglobulin, Antibody, T cell receptor, Somatic hypermutation, Allelic polymorphism, High-throughput sequencing, IMGT-ONTOLOGY
      description:IMGT/V-QUEST is the highly customized and integrated online IMGT® tool for the standardized analysis of the immunoglobulin (IG) or antibody and T cell receptor (TR) rearranged nucleotide sequences. The analysis of these antigen receptors represents a crucial challenge for the study of the adaptive immune response in normal and disease-related situations. The expressed IG and TR repertoires represent a potential of 1012 IG and 1012 TR per individual. This huge diversity results from mechanisms that occur at the DNA level during the IG and TR molecular synthesis. These mechanisms include the combinatorial rearrangements of the variable (V), diversity (D) and joining (J) genes, the N-diversity (deletion and addition at random of nucleotides during the V-(D)-J rearrangement) and, for IG, somatic hypermutations. IMGT/V-QUEST identifies the V, D, J genes and alleles by alignment with the germline IG and TR gene and allele sequences of the IMGT reference directory. The tool describes the V-REGION mutations and identifies the hot spot positions in the closest germline V gene. IMGT/V-QUEST integrates IMGT/JunctionAnalysis for a detailed analysis of the V-J and V-D-J junctions and IMGT/Automat for a complete annotation of the sequences and also provides IMGT Collier de Perles. IMGT/HighV-QUEST, the high-throughput version of IMGT/V-QUEST, implemented to answer the needs of deep sequencing data analysis from Next Generation Sequencing (NGS), allows the analysis of thousands of IG and TR sequences in a single run. IMGT/V-QUEST and IMGT/HighV-QUEST are available at the IMGT® Home page, http://www.imgt.org .
      datePublished:2012
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      context:https://schema.org
Book:
      name:Immunogenetics
      isbn:
         978-1-61779-842-9
         978-1-61779-841-2
Organization:
      name:Humana Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
      address:
         name:IMGT®, the International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
         type:PostalAddress
      name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
      address:
         name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
         type:PostalAddress
      name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142
      address:
         name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142, Montpellier, France
         type:PostalAddress
      name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
      address:
         name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Eltaf Alamyar
      affiliation:
            name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
            address:
               name:IMGT®, the International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Patrice Duroux
      affiliation:
            name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
            address:
               name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Marie-Paule Lefranc
      affiliation:
            name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142
            address:
               name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142, Montpellier, France
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Véronique Giudicelli
      affiliation:
            name:Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142
            address:
               name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:IMGT®, the International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
      name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
      name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS1142, Montpellier, France
      name:IMGT®, The International ImMunoGeneTics Information System®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UPR CNRS 1142, Montpellier, France
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