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Title[redir]:
IL-1–induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation - PMC
Description:
Lin et al. show that Bhlhe40 expression identifies encephalitogenic CD4+ T helper cells and define a pertussis toxin–IL-1–Bhlhe40 pathway active in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
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Keywords {🔍}
cells, mice, bhlhe, expression, gfppos, ptx, eae, bhlhegfp, pubmed, google, scholar, doi, data, fig, cell, ilβ, day, gfpneg, shown, gfp, gmcsf, production, experiments, pmc, article, mogcfa, immunization, free, induction, ifnγ, experiment, immunol, performed, combined, cytokine, cns, autoimmune, ilr, quantitation, naive, pertussis, ila, frequency, dln, expressed, immunized, showed, signaling, disease, treatment,
Topics {✒️}
bacterial artificial chromosome heat-killed mycobacterium tuberculosis myelin oligodendrocyte glycoprotein-specific basic helix–loop–helix–orange subfamily myelin oligodendrocyte glycoprotein ifn-γ/il-17/gm-csf triple-producing cells granulocyte-macrophage colony-stimulating factor percp-efluor710 anti-pro–il-1β mog38-49–i-ab tetramer staining inflammasome-derived il-1β regulates intracellular cytokine staining mhc ii+ly6c+ monocytes/modcs apc mog38–49–i-ab tetramers il-1/il-1r antagonist system ongoing myelin-specific response bone marrow–derived dcs/macrophages performed intracellular staining antigen-specific gm-csf–producing pe-cy7 anti–ifn-γ proposed positive-feedback loop cell–derived gm-csf served ptx–treated mog/cfa-immunized mice andreasen dc adp-ribosylating exotoxin derived goat anti–rat igg interferon-β-expressing th17 cells ifn-γ-producing th17 cells il-1r–sufficient bhlhe40gfp cells ptx–il-1–bhlhe40 pathway active quantitative real-time pcr anti–rabbit igg-hrp mhc class ii pmc beta search experimental autoimmune encephalomyelitis mog38-49–i-ab tetramers mog38–49–i-ab tetramers transcription factor t-bet transcription factor c-maf plate bound anti-cd3 quantitative rt-pcr analysis antigen-specific ifn-γ recombinant human tgf-β1 pmc copyright notice pi-3k–akt pathway bac transgenic project cells secreting ifn-γ pe-cy7 anti-ly6g mog-specific cells producing promoted il-1β production
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